Fazle Azim

Comparative Efficacy Of Hormonal & Surgical Treatment For Pymetra In The Dog - 1991

Pyometra is one of the serious disorders of the female reproductive system in the dog. It can lead to infertility in some cases and death in others. Ovariohysterectomy is believed to be the treatment of choice for pyometra but the reproductive potential of the animal is lost during this process. That is why ovariohysterectomy is of no value in breeding animals. Therefore, there must be an alternative treatment to save the animal and its reproductive ability. This project was designed with the same idea in mind.

For this experiment twenty clinically healthy female mongrel dogs were selected and were injected with progesterone for 5 days to initiate the hyperplasia of their uteri. The cervices of these animals were dilated by giving them Stilboesterol injections for two days. Thereafter pathogenic culture of Escherichia coil was inoculated within the hyperplastic uteri to induce pyometra. Then these animals were reswitched to progesterone therapy for 5 more days/ Pyometra was confirmed by clinical signs and white blood cell counts, which were found increased 2-4 folds, 5-7 days after inoculation.

The diseased animals were divided into two groups, group I (Surgical treatment group) and group II (Hormonal therapy group), consisting of 10 animals each. In the group I, ovariohysterectomy was performed and these animals were divided into two subgroups Ia and lb, consisting of 5 animals each. The animals of group Ia were kept on antibiotics only whereas the animals of group lb were kept on antibiotics and intravenous fluids, post operatively. The animals of group II were kept on Prostaglandins for treatment. This group was also divided into two subgroups Ila and Nb (consisting of 5 animals each). The animals of group Na were kept on antibiotics only and the animals of group lib were kept on antibiotics and intravenous fluids, during the hormonal therapy.

All the animals of surgical treatment group (Ia and Ib) responded to the treatment very nicely and 100 per cent recovery rate was recorded. In the hormonal therapy group (ha and Nb) 60 per cent recovery rate was recorded, as one animal of group Ila died due to shock on the 2nd day of hormonal therapy and one animal did not respond to the hormonal therapy. Among the 5 animals of group lIb, 2 animals did not respond to the treatment. Although 60 per cent recovery rate was observed in the hormonal therapy group but serious side effects of prostaglandins were also noticed (vomiting, restlessness, defecation and urination was observed just after the prostaglandin injection). As far as the supportive therapy (intravenous fluids) was concerned it did not affect the recovery rate of the animals and there was no noticeable difference between the blood analysis and urinalysis of the animals kept on intravenous fluids and those which did not receive intravenous fluids.

The analysis of the results indicated that no doubt ovariohysterectomy has an edge over the prostaglandins therapy in cases of pyometra. However, ovariohysterectomy should be advised in those cases where the dog is a mediocre one and the owner is interested in saving the life and not the reproductive potential of the animal. But in cases where the dog belongs to a breeding stock with a very good pedigree record, and the owner is particularly interested in her reproductive ability, one should not hesitate to try the hormonal therapy, as based upon the findings of this research at least 60 per cent chances exists to get that end.

Department of Clinical Medicine & Surgery


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