Shafeeq-ur-Rahman Kailani

Studies On The Efficacy Of Indigenous Drugs Against Fascioliasis In Buffaloes - 1991

Experiments have been carried out to study the antifasciolic effects of the powdered plant drugs including Nigella sativa (seeds), Fumaria paryiflora (aerial parts) and Caesalpinia crista(seeds) in buffaloes suffering naturally from fascioliasis. The chronological effects of these indigenous drugs on a reduction of faeeal EPG counts of the experimental arLimala on 3rd, 10th and 15th day post medication were recorded. All the drugs, in the presiribed dose levels were administered orally as a single dose treatment to the animals of specified drug and dose group.

Incidence of fascioliasis from random samplings were found to be 3306±0.74 percent arid from symptomatically selected samples to be 64±3.18 percent.

All the crude drugs were found to cause a chronological increase in their percentage efficacies against chronic fascioliasis, when tested on post-treatment days 3rd, 10th and 15th. Both the parameters C dosage level as well as the post treatment days ) caused significant effects on the efficacies in all the drugs, as indicated by the values of their F-ratios. All the drugs showed the upper most dosage level (L3) to be the optimum dosage level with a highly significant (P<0.005) decrease in the egg-counts on all the post treatment days checked. On the post treatment day 3rd, all the drugs caused a non-significant decrease in the egg-counts at their lowest dosage level, a significant change at their upper dosage level and a highly significant decrease at their upper most dosage level (L3). However within the prescribed dosage levels, none of the drugs could decrease the egg-counts to zero(0), on post treatment day 15th, indicating that some betterment, of course, would be possible by a slight increase in the dosage levels in all the drugs. Maximum efficacy, on the basis of percentage egg- count reductions(s), was shown by Fumaria paryiflora (Shahtera) (93.15+ 0.51), while Caesalpinia crista (Karanjwa) (89.67+1.7) and Nigella stiva (karanjwa) (88.17±0.41 percent) indicated to he on second and third position respectively.

Department of Clinical Medicine & Surgery


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