Fouzia Iqbal
Comparative Ealuation Of Melia Azadarch Linn (Neem) For Control Of Coccidiosis In Poultry (Broiler) - 1993
A study was conducted to evaluate the anti-coccidial activity of Melia azadarch Linn (Neem) , an indigenous plant drug in comparison to synthetic coccicliostats (Esb3) in broilers.
The Meli azadarch Linn (Neem) seed was tried in powder, aquous extract and methanolic extract for anti-coccidial activity in broilers. The birds were artificial infected with coccidial oocyst at the age of 30 days. After 5 days of infection the oocyst counting was carried out in the droppings of the birds. When evidence of coccidiosis outbreak in the infected birds was established than the drug was administered to different groups of the broilers. The group A was kept as control, group B, C & D were administered Powder Melia azadarch Linn (Neem) 10, 20 & 30 mg/Kg body weight respectively and group F was given Esb3, to compare the effect of this plant drug. Similarly aquous extract and Methanolic extract was administered equivalent to 10, 20 & 30 mg/Kg B.W. of Melia azadaich Linn (Neem) to respective group. The OPG (oocyst per gram) was examined after 3, 10 & 15 days after the drug administration. It was observed that OPG (oocyst per gram) was decreased to 0.59%, 0.78% and 0.58% at the dose rate of 10, 20 and 30 mg/Kg 13.W. respectively after 3 clays of treatment with Melia azadarch Linn Powder. Whereas it was reduced to 82.79% in group E treated with Esb3. After 10 days of treatment OPG was decreased to 50.17% and 96.55% in groups B, C, D & E respectively at the dose rate oF 10, 20 & 30 mg/Kg [3.W. in case of Melia azadarch Linn (Powder) and lsb1. After 15 days OPG was decreased to 97.94%, 97.08%, 97.87 and 98.60% in group B, C, D & E respectively in case of Melia azadarch Linn (Powder) at the dose rate of 10, 20 and 30 mg/Kg 13.W. and Esb3. at dose rate of 1g/liter.
In case of Melia azadarch Linn (Neern) (Water extract) OPG reduction after 3 days of treatment was 4.46%, 3,93% and
3.67% in groups B, C and 1). While OPG reduction in case of group E was 83.82%.
After 10 days of post treatment OPG counting was 5 1.33%, 51.18%, 51,10% and 96.76 in groups 13, C, 1) and E respectively. In case of OPG counting after 15 days reduction was 90.62%, 86.61%, 79.77% and 98.30% in groups 13, C, I) and l respectively. Dose rate of group B, C, & 1) is equivalent to 10, 20 & 30 mglKg B.W. and group E ig/liter i.e. Esb3:,.
In case of group treated with Melia azaclarch Linn (Neem) (methanolic extract, OPG reduction after 3 days of treatment was 0.59%, 0.78%, 0.58% and 82.79% in groups B, C, D & E respectively. In case OPG counting after 10 days of treatment was 50.17%, 50.23%, 50.17% and 96.55% in groups B, C, D & E respectively. While OPG counting after 15 clays of treatment was 97.94%, 97.08%, 97.87% and 98.60% in groups B, C, D & E. Dose rate of group B, C, D was equivalent to dose rate of 10, 20 and 30mg/kg .B.W. & group E was t ieated with I1sb at dose rate of ig/liter.
It is concluded that. Melia azadarch Linn (Neem ) is equally effective against coccidiosis in powder, aquous and methanolic extract. Although it took longer to produce similar effect as Esb3 but it is quite comparable with the results shown by 1sb. In addition the Melia azadarch linn (Neem). in either from did not show any adverse effect on the growth rate of the broilers. Any how this plant material can be used as prophylactic measures or to treat the outbreak of coccidiosis. Certainly there is a need for investigation to make this drug more efficacious.
Department of Pharmaoclogy & Toxicology
0384,T
Comparative Ealuation Of Melia Azadarch Linn (Neem) For Control Of Coccidiosis In Poultry (Broiler) - 1993
A study was conducted to evaluate the anti-coccidial activity of Melia azadarch Linn (Neem) , an indigenous plant drug in comparison to synthetic coccicliostats (Esb3) in broilers.
The Meli azadarch Linn (Neem) seed was tried in powder, aquous extract and methanolic extract for anti-coccidial activity in broilers. The birds were artificial infected with coccidial oocyst at the age of 30 days. After 5 days of infection the oocyst counting was carried out in the droppings of the birds. When evidence of coccidiosis outbreak in the infected birds was established than the drug was administered to different groups of the broilers. The group A was kept as control, group B, C & D were administered Powder Melia azadarch Linn (Neem) 10, 20 & 30 mg/Kg body weight respectively and group F was given Esb3, to compare the effect of this plant drug. Similarly aquous extract and Methanolic extract was administered equivalent to 10, 20 & 30 mg/Kg B.W. of Melia azadaich Linn (Neem) to respective group. The OPG (oocyst per gram) was examined after 3, 10 & 15 days after the drug administration. It was observed that OPG (oocyst per gram) was decreased to 0.59%, 0.78% and 0.58% at the dose rate of 10, 20 and 30 mg/Kg 13.W. respectively after 3 clays of treatment with Melia azadarch Linn Powder. Whereas it was reduced to 82.79% in group E treated with Esb3. After 10 days of treatment OPG was decreased to 50.17% and 96.55% in groups B, C, D & E respectively at the dose rate oF 10, 20 & 30 mg/Kg [3.W. in case of Melia azadarch Linn (Powder) and lsb1. After 15 days OPG was decreased to 97.94%, 97.08%, 97.87 and 98.60% in group B, C, D & E respectively in case of Melia azadarch Linn (Powder) at the dose rate of 10, 20 and 30 mg/Kg 13.W. and Esb3. at dose rate of 1g/liter.
In case of Melia azadarch Linn (Neern) (Water extract) OPG reduction after 3 days of treatment was 4.46%, 3,93% and
3.67% in groups B, C and 1). While OPG reduction in case of group E was 83.82%.
After 10 days of post treatment OPG counting was 5 1.33%, 51.18%, 51,10% and 96.76 in groups 13, C, 1) and E respectively. In case of OPG counting after 15 days reduction was 90.62%, 86.61%, 79.77% and 98.30% in groups 13, C, I) and l respectively. Dose rate of group B, C, & 1) is equivalent to 10, 20 & 30 mglKg B.W. and group E ig/liter i.e. Esb3:,.
In case of group treated with Melia azaclarch Linn (Neem) (methanolic extract, OPG reduction after 3 days of treatment was 0.59%, 0.78%, 0.58% and 82.79% in groups B, C, D & E respectively. In case OPG counting after 10 days of treatment was 50.17%, 50.23%, 50.17% and 96.55% in groups B, C, D & E respectively. While OPG counting after 15 clays of treatment was 97.94%, 97.08%, 97.87% and 98.60% in groups B, C, D & E. Dose rate of group B, C, D was equivalent to dose rate of 10, 20 and 30mg/kg .B.W. & group E was t ieated with I1sb at dose rate of ig/liter.
It is concluded that. Melia azadarch Linn (Neem ) is equally effective against coccidiosis in powder, aquous and methanolic extract. Although it took longer to produce similar effect as Esb3 but it is quite comparable with the results shown by 1sb. In addition the Melia azadarch linn (Neem). in either from did not show any adverse effect on the growth rate of the broilers. Any how this plant material can be used as prophylactic measures or to treat the outbreak of coccidiosis. Certainly there is a need for investigation to make this drug more efficacious.
Department of Pharmaoclogy & Toxicology
0384,T