Zubair, M

Comparative Efficacy On Newly Introduced Antibacterial Drugs Against Experimentally Induced Escherichia Coli - 1996

Pakistan faces an acute shortage of animal protein which is acknowledged as a serious problem at national level. Since broilers are the fastest converters of crude protein into digestible high quality protein for human consumption. There is much need in the production of broilers for the said reason in Pakistan. The upgrading of poultry industry is suffered from huge losses caused by certain diseases of bacterial origin. Amongst bacterial diseases, Escherichia coli is the worst threat to poultry industry. Therefore, concrete and consistent effort was done in this project to control the Eschericia coli infection.

The present project was done to study the efficacy of different drugs on prevalent strains of E. coli isolated from broilers that were collected from Diagnostic Laboratory, office of the Project Director, Poultry Production, 16-Cooper Road, Lahore and various Farms in the vicinity of Lahore.

Six different antibacterial drugs which comprised of avitryl, advocin, plasmacolin, flumequine gentamicin and inoxyl were used to check the sensitivity of the isolates. In-vitro the sensitivity results was in this order avitryl, advocin, plasmacolin, gentamicin, flumeuine and inoxyl respectively. Avitryl emerged as best drug.

The pathogenicity of the isolated strains was tested in albino mice taken from V.R.I., Lahore. The confirmed pathogenic isolates of . coli were diluted upto 3x108 bacteria per 0.25 ml, this dilution ws made after doing total viable count and the dose was injected intra-peritoneally to five albino mice while 5 albino mice were kept as controls.

These six drugs were further tested for their efficiency in broilers against . coli infection. A total of two hundred and forty birds reared upto four weeks of age and then they were divided into eight groups, A, B, C, D, E, F, G and H, each having 30 birds. Group H was kept as non-infected and non- treated. While Group G was infected but not treated. The remaining groups A, B, C, D, E and F, 16 hours after infection were treated with avitryl, advocin, plasmacolin, flumequine, gentamicin and inoxyl for five days respectively. All the groups were kept under close observation and their mortality and feed efficiency was noted.
In group G maximum mortality was noted i.e. 57.14 while in the group A, B, C, D, E and F, the mortality recorded was 22.72, 30, 33.33, 40.90, 47.82 and 52.17 respectively.

Avitryl was proved to be the highest protection against coli infection and best in relation to F.C.R. by this experiment.

Department of Clinical Medicine & Surgery


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