Farhan Ahmad Atif

Evaluation Of Liver Functions At Varying Degrees Of Hepatectomy In Dogs - 1999

Liver is the most important organ because of its multiplicity of functions. It played a pivotal rote in the nutrition and maintenance of the body.

In this project 16 dogs were taken and divided into 4 groups comprising 4 dogs each. In group-A total removal of right lateral lobe was performed. In group-B half part of the right lobe was resected. Group-C was sham operated in which only laparotomy was experienced. Whereas, group-D acted as control.

Liver function tests were conducted in all the groups before and after surgery. rfhe.e was slight elevation in the values of liver enzymes which remained within the normal range except alkaline phosphatase.

Metabolic ability was not affected appreciably after resection of half and complete removal of right lateral lobe.

All the dogs were euthanized after 8 weeks post-operatively. The dogs of group-B showed hepatic regeneration that was 31.2, 38.8 and 28.3 percent in dog No.6, 7 and 8 respectively. The histopathology of regenerated tissue revealed normal hepatic tissue.

The analysis of results has clearly indicated that resection of liver upto this extent does not alter liver functions noticeably and thus partial hepatectomy can be performed without any fear.

Department of Clinical Medicine & Surgery


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