Hafiz Muhammad Irfan
Effect Of Levamisole On The Cholinesterase Inhibition By Trichlorfon In Rabbits - 2007
This project was designed in female rabbits to find out Trichiorfon- induced toxicosis and its interaction with Levamisole by inhibiting cholinesterase enzyme, taking account of the administration of levamisole before trichiorfon dosing. For this purpose, twenty female rabbits with weights of 1.0kg to 1.9kg were divided into four groups. Each group (A, B, C and D) containing five rabbits. Group 'A' was considered as control, group B was given trichiorfon 10mg/kg body weight (orally), while group 'C' was treated with levamisolelomg/kg (S/C) and then trichiorfon 10mg/kg (orally) after 30minutes of levamisole and the group 'D' was given levamisole 10mg/kg (S/C). After determination of butyryl cholinesterase activity, alkaline phosphatase activity, aspartate aminotransferase activity and alanine aminotransferase activity, it was observed that Trichiorfon and Levamisole significantly inhibited butyryl cholinesterase enzyme at 10mg/kg body weight Where as Levamisole pretreatment did not potentiate the inhibitory activity of Trichlorfon at 10mg/kg body weight dosage whether the Levamisole was given subcutaneously or orally. The alkaline phosphatase activity was increased significantly with Trichiorfon and Levamisole had no significant effect on it while the effect on aspartate aminotransferase was non significant. The alanine aminotransferase activity was decreased significantly with Levamisole. The results also showed that the time interval between Levamisole and Trichiorfon dosage and route of administration did not affect the cholinesterase activity. No clinical signs and postmortem lesions were observed at 10mg/kg body weight dosage while Levamisole at 50mg/kg body weight, produced signs of toxicosis. In general, there was no adverse drug interaction between Levamisole and Trichlorfon.
Department of Pharmaoclogy & Toxicology
0975,T
Effect Of Levamisole On The Cholinesterase Inhibition By Trichlorfon In Rabbits - 2007
This project was designed in female rabbits to find out Trichiorfon- induced toxicosis and its interaction with Levamisole by inhibiting cholinesterase enzyme, taking account of the administration of levamisole before trichiorfon dosing. For this purpose, twenty female rabbits with weights of 1.0kg to 1.9kg were divided into four groups. Each group (A, B, C and D) containing five rabbits. Group 'A' was considered as control, group B was given trichiorfon 10mg/kg body weight (orally), while group 'C' was treated with levamisolelomg/kg (S/C) and then trichiorfon 10mg/kg (orally) after 30minutes of levamisole and the group 'D' was given levamisole 10mg/kg (S/C). After determination of butyryl cholinesterase activity, alkaline phosphatase activity, aspartate aminotransferase activity and alanine aminotransferase activity, it was observed that Trichiorfon and Levamisole significantly inhibited butyryl cholinesterase enzyme at 10mg/kg body weight Where as Levamisole pretreatment did not potentiate the inhibitory activity of Trichlorfon at 10mg/kg body weight dosage whether the Levamisole was given subcutaneously or orally. The alkaline phosphatase activity was increased significantly with Trichiorfon and Levamisole had no significant effect on it while the effect on aspartate aminotransferase was non significant. The alanine aminotransferase activity was decreased significantly with Levamisole. The results also showed that the time interval between Levamisole and Trichiorfon dosage and route of administration did not affect the cholinesterase activity. No clinical signs and postmortem lesions were observed at 10mg/kg body weight dosage while Levamisole at 50mg/kg body weight, produced signs of toxicosis. In general, there was no adverse drug interaction between Levamisole and Trichlorfon.
Department of Pharmaoclogy & Toxicology
0975,T