Abhullah khan
A Study Of Detection & Chemotherapy Ascariasis In Paddock Horses,Donkeys & Mules. - 2008
Equines constitute an important and integral part of livestock of the country for their utility and service. Parasitic infections pose an inevitable threat to the equine industry. Ascariasis is one of the major veterinary problems of developed and under developed countries of the world. It is considered to be highly responsible for great economic losses in the form of stunted growth, weight loss and death in severe cases. Keeping in view, the present study was conducted to find out the prevalence of ascariasis among paddock horses, donkeys and mules along with evaluating the efficacy of anthelmintics for therapeutic and prophylactic use.
For this purpose paddock horses (n150), donkeys (n=150) and mules (n150) of Army Remount Depot Mona were examined coprologically for ascarids and their The faecal samples were processed at Medicine Laboratory, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore by Direct Smear Method and Salt Flotation Technique for detection of ascarid eggs, while eggs per gram (EPG) of faeces were determined by employing McMaster Egg Counting Technique. The overall prevalence of Ascariasis in paddock horses, donkeys and mules was recorded as 36.00%, 31.33% and 28% respectively. The infection rate was higher in animals of fewer than 2 years of age i.e. 64, 56 and 52 percent as compared to animals over 2 years old i.e. 22, 19 and 16 percent respectively. For chemotherapy trials the positive cases from each category were divided into three groups consisting of six animals each. The animals of first group were treated with Doramectin @ 0.2mg/kg body weight subcutaneously, second group with Garlic 0.2gm/kg body weight orally and the third group kept as positive control. A fourth group consisting of six negative animals from each category was kept as negative control. Eggs per gram (EPG) of animals of all the groups were determined at Day 0 (Pre-treatment) and day 3, 7, and 14 (Post-treatment). The efficacy of the drugs was determined on the basis of reduction in EPG.
The efficacy of Doramectin against the ova /larvae of Parascaris
equorum was recorded as 81.48%, 92.59% and 92,59% at day 3, 7 and 14 respectively in horses, 41.93%, 87.10% and 80.64% at day 3, 7 and 14 respectively in donkeys and 66.66%, 81,48%and 81.48% at day 3, 7 and 14 respectively in mules. The efficacy of Garlic Powder was very low as compared to Doramectin and recorded as 44.44%, 48.15% and 44.44% at day 3, 7 and 14 respectively in horses, 37.95%, 5 1.61% and 5 1.61% at day 3, 7 and 14 respectively in donkeys and 18.52%, 33.33% and 33.33% respectively in mules. Low efficacy of Garlic may be due to insufficient extraction of allicin, the antiparasitic ingredient in garlic. Thus further study is recommended to determine the safe and efficacious dose rate and frequency of garlic to obtain desired anthelmintic effect of allicin.
Statistical analysis of the data revealed significant difference between drugs (Doramectin and Garlic power) and between control and treated groups of horses, donkeys and mules.
Department of Clinical Medicine & Surgery
1031,T
A Study Of Detection & Chemotherapy Ascariasis In Paddock Horses,Donkeys & Mules. - 2008
Equines constitute an important and integral part of livestock of the country for their utility and service. Parasitic infections pose an inevitable threat to the equine industry. Ascariasis is one of the major veterinary problems of developed and under developed countries of the world. It is considered to be highly responsible for great economic losses in the form of stunted growth, weight loss and death in severe cases. Keeping in view, the present study was conducted to find out the prevalence of ascariasis among paddock horses, donkeys and mules along with evaluating the efficacy of anthelmintics for therapeutic and prophylactic use.
For this purpose paddock horses (n150), donkeys (n=150) and mules (n150) of Army Remount Depot Mona were examined coprologically for ascarids and their The faecal samples were processed at Medicine Laboratory, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore by Direct Smear Method and Salt Flotation Technique for detection of ascarid eggs, while eggs per gram (EPG) of faeces were determined by employing McMaster Egg Counting Technique. The overall prevalence of Ascariasis in paddock horses, donkeys and mules was recorded as 36.00%, 31.33% and 28% respectively. The infection rate was higher in animals of fewer than 2 years of age i.e. 64, 56 and 52 percent as compared to animals over 2 years old i.e. 22, 19 and 16 percent respectively. For chemotherapy trials the positive cases from each category were divided into three groups consisting of six animals each. The animals of first group were treated with Doramectin @ 0.2mg/kg body weight subcutaneously, second group with Garlic 0.2gm/kg body weight orally and the third group kept as positive control. A fourth group consisting of six negative animals from each category was kept as negative control. Eggs per gram (EPG) of animals of all the groups were determined at Day 0 (Pre-treatment) and day 3, 7, and 14 (Post-treatment). The efficacy of the drugs was determined on the basis of reduction in EPG.
The efficacy of Doramectin against the ova /larvae of Parascaris
equorum was recorded as 81.48%, 92.59% and 92,59% at day 3, 7 and 14 respectively in horses, 41.93%, 87.10% and 80.64% at day 3, 7 and 14 respectively in donkeys and 66.66%, 81,48%and 81.48% at day 3, 7 and 14 respectively in mules. The efficacy of Garlic Powder was very low as compared to Doramectin and recorded as 44.44%, 48.15% and 44.44% at day 3, 7 and 14 respectively in horses, 37.95%, 5 1.61% and 5 1.61% at day 3, 7 and 14 respectively in donkeys and 18.52%, 33.33% and 33.33% respectively in mules. Low efficacy of Garlic may be due to insufficient extraction of allicin, the antiparasitic ingredient in garlic. Thus further study is recommended to determine the safe and efficacious dose rate and frequency of garlic to obtain desired anthelmintic effect of allicin.
Statistical analysis of the data revealed significant difference between drugs (Doramectin and Garlic power) and between control and treated groups of horses, donkeys and mules.
Department of Clinical Medicine & Surgery
1031,T