Muhammad Jameel
Prevalence Of Gryptosporidiosis In Per Dogs And Comparative Efficacy Of Azithromycin, Clindamycin And Tylosin - 2011
Cryptosporidiosis is one of the important parasitic diseases of dogs and other canine and feline species which is of special concern with reference to the immuno-compromised individuals. Several trials have been run to estimate the prevalence and treatment of the said disease in different regions of the globe, in immuno-competent and in immuno-compromised patients as well.
The aim of this study was not only to determine the prevalence of Cryptosporidiosis in pet dogs in the Lahore district but to evaluate the comparative efficacy of Azithromycin, Clindamycin, Tylosine and combination of Clindamycin and Tylosine as well. For this purpose, in first phase of the trial, oocyst enumeration was performed in 300 samples collected from three different clinics in Lahore district. The prevalence was found to be 21.33%. In the second phase, 32 Cryptosporidiosis positive dogs were selected and were randomly divided into four equal groups. These four groups of dogs were given afore-mentioned dosages of the above mentioned drugs and oocyst count was done on d 7, d 14 and d 21.
The results revealed that Azithromycin proved itself as the most successful drug in elimination of Cryptosporidium in dogs as it showed 79.26% efficacy as compared to the combination of Clindamycin and Tylosine (43.58%), Clindamycin (26.53%) and Tylosine (16.03%). It should be stated that the future trials may manipulate the dose rates and the period of therapy to achieve even better results. The efficacy results for the combination of Clindamycin and Tylosine also suggested a positive innovation in its regimen in future studies. And last but not least, the efficacy percentages of Clindamycin and Tylosine (as individual drugs) demonstrated them poor drugs to be used against Cryptosporidiosis specifically in dogs atleast in context of the dosage regimens and therapeutic periods employed in the current study.
Department of Clinical Medicine & Surgery
1344,T
Prevalence Of Gryptosporidiosis In Per Dogs And Comparative Efficacy Of Azithromycin, Clindamycin And Tylosin - 2011
Cryptosporidiosis is one of the important parasitic diseases of dogs and other canine and feline species which is of special concern with reference to the immuno-compromised individuals. Several trials have been run to estimate the prevalence and treatment of the said disease in different regions of the globe, in immuno-competent and in immuno-compromised patients as well.
The aim of this study was not only to determine the prevalence of Cryptosporidiosis in pet dogs in the Lahore district but to evaluate the comparative efficacy of Azithromycin, Clindamycin, Tylosine and combination of Clindamycin and Tylosine as well. For this purpose, in first phase of the trial, oocyst enumeration was performed in 300 samples collected from three different clinics in Lahore district. The prevalence was found to be 21.33%. In the second phase, 32 Cryptosporidiosis positive dogs were selected and were randomly divided into four equal groups. These four groups of dogs were given afore-mentioned dosages of the above mentioned drugs and oocyst count was done on d 7, d 14 and d 21.
The results revealed that Azithromycin proved itself as the most successful drug in elimination of Cryptosporidium in dogs as it showed 79.26% efficacy as compared to the combination of Clindamycin and Tylosine (43.58%), Clindamycin (26.53%) and Tylosine (16.03%). It should be stated that the future trials may manipulate the dose rates and the period of therapy to achieve even better results. The efficacy results for the combination of Clindamycin and Tylosine also suggested a positive innovation in its regimen in future studies. And last but not least, the efficacy percentages of Clindamycin and Tylosine (as individual drugs) demonstrated them poor drugs to be used against Cryptosporidiosis specifically in dogs atleast in context of the dosage regimens and therapeutic periods employed in the current study.
Department of Clinical Medicine & Surgery
1344,T