Naveed Hussain
Clinico-Biochemical Study After Partial And Complete Blockage Of Ureters In Dogs. - 2012
Ureteral obstruction is one of the most common problems associated with urinary system. It imparts serious consequences on the system, if not treated sharply. The present study was performed in twenty dogs after producing experimental obstruction through ureteral ligations of variable nature.
The aim of the experiment was to identify the effects of variable ligations on obstructed and contralateral kidney with the help of blood parameters including hematology and serum analysis along with diagnostic imaging i.e. radiography and ultrasonography. It was noted that hematology was of least significance as diagnostic aid while serum analysis i.e. BUN and S/Cr were of some worth in early stages. As far as diagnostic imaging was concerned IV urography is considered as first line diagnosis in advanced cases revealing kidney size, parenchyma and hydronephrosis, while Ultrasonography is more sophisticated and advanced which is helpful in initial diagnosis and can study deep structures of the kidney.
Results revealed that in partial obstructions, in obstructed kidneys severity of hydronephrosis and kidney damage was less than complete obstructions. In complete ureteral obstruction, deterioration of total internal structures including medulla , cortex and renal pelvis was observed. Role of contralateral kidney was also evident during the experiment, which compensated the physiological changes due to obstruction and helped the patient in returning to normal life but structural damage of variable nature was also noted depending upon the severity of obstruction in the ureter.
It was observed during experiment that the revival of renal function is time dependent which is inversely related to duration of obstruction. If obstruction, mild or severe, is released earlier, recovery is quick and complete renal function restoration is possible in 24 to 48 hours of obstruction, depending upon its severity. But if delay occurs, it results in irreversible damage to the obstructed kidney and after three to six weeks no functional parenchyma is detectable in severe and mild obstructions respectively.
Department of Clinical Medicine & Surgery
1450,T
Clinico-Biochemical Study After Partial And Complete Blockage Of Ureters In Dogs. - 2012
Ureteral obstruction is one of the most common problems associated with urinary system. It imparts serious consequences on the system, if not treated sharply. The present study was performed in twenty dogs after producing experimental obstruction through ureteral ligations of variable nature.
The aim of the experiment was to identify the effects of variable ligations on obstructed and contralateral kidney with the help of blood parameters including hematology and serum analysis along with diagnostic imaging i.e. radiography and ultrasonography. It was noted that hematology was of least significance as diagnostic aid while serum analysis i.e. BUN and S/Cr were of some worth in early stages. As far as diagnostic imaging was concerned IV urography is considered as first line diagnosis in advanced cases revealing kidney size, parenchyma and hydronephrosis, while Ultrasonography is more sophisticated and advanced which is helpful in initial diagnosis and can study deep structures of the kidney.
Results revealed that in partial obstructions, in obstructed kidneys severity of hydronephrosis and kidney damage was less than complete obstructions. In complete ureteral obstruction, deterioration of total internal structures including medulla , cortex and renal pelvis was observed. Role of contralateral kidney was also evident during the experiment, which compensated the physiological changes due to obstruction and helped the patient in returning to normal life but structural damage of variable nature was also noted depending upon the severity of obstruction in the ureter.
It was observed during experiment that the revival of renal function is time dependent which is inversely related to duration of obstruction. If obstruction, mild or severe, is released earlier, recovery is quick and complete renal function restoration is possible in 24 to 48 hours of obstruction, depending upon its severity. But if delay occurs, it results in irreversible damage to the obstructed kidney and after three to six weeks no functional parenchyma is detectable in severe and mild obstructions respectively.
Department of Clinical Medicine & Surgery
1450,T