Solid Phase Dispersion Technique For Enhancing Water Solubility Of Diclofenac Sodium (Record no. 11096)

000 -LEADER
fixed length control field 02206nam a22002177a 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20170523123738.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170523b2016 xxu||||| |||| 00| 0 eng d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 2718-T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Sana Javed (2013-VA-901)
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Muhammad Nabeel Shahid
245 ## - TITLE STATEMENT
Title Solid Phase Dispersion Technique For Enhancing Water Solubility Of Diclofenac Sodium
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 2016.
300 ## - PHYSICAL DESCRIPTION
Number of Pages 61p.;
502 ## - DISSERTATION NOTE
Dissertation note Improving oral drug absorption and bioavailability is a major issue with the pharmaceutical industries and a number of approaches to enhance the intestinal absorption of drugs have been taken up. Particle size reduction has been proved an important aid in improving bioavailability and drug delivery by increasing the solubility and dissolution rates of poorly soluble drugs.
In this study, Diclofenac Sodium was formulated with polyethylene glycol in different ratios to examine the effect of concentration of carriers on properties of diclofenac sodium and how it enhances the aqueous solubility of drug. Diclofenac sodium and other powder mixtures were characterized by compressibility, bulk and tapped density, angle of repose, solubility and dissolution. The data on flow properties, solubility and dissolution was calculated for comparative analysis of diclofenac sodium in bulk with formulated solid dispersion. Results showed improved flow of powders and improved water solubility of drug. The solubility and dissolution data showed the better results for the formulation with code SDF2. The physicochemical characteristics of the prepared formulations were assessed by differential scanning calorimetry, Fourier transform infrared spectroscopy and scanning electron microscopy. The DSC and FTIR studies revealed that there was no interaction between drug and carriers. It was concluded that the SD prepared by solvent evaporation technique using hydrophilic polymer enhanced solubility and dissolution and hence better patient compliance and effective therapy.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Pharmaceutics
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Pharmaceutical Sciences
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr. Farzana Chowdhary
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Prof. Dr. Muhammad Ashraf
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2017-05-23 2718-T 2718-T Thesis


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