Solid Phase Dispersion Technique For Enhancing Water Solubility Of Diclofenac Sodium (Record no. 11096)
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000 -LEADER | |
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fixed length control field | 02206nam a22002177a 4500 |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20170523123738.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 170523b2016 xxu||||| |||| 00| 0 eng d |
041 ## - LANGUAGE CODE | |
Language code of text/sound track or separate title | eng |
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 2718-T |
100 ## - MAIN ENTRY--AUTHOR NAME | |
Personal name | Sana Javed (2013-VA-901) |
110 ## - MAIN ENTRY--CORPORATE NAME | |
Location of meeting | Muhammad Nabeel Shahid |
245 ## - TITLE STATEMENT | |
Title | Solid Phase Dispersion Technique For Enhancing Water Solubility Of Diclofenac Sodium |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
Year of publication | 2016. |
300 ## - PHYSICAL DESCRIPTION | |
Number of Pages | 61p.; |
502 ## - DISSERTATION NOTE | |
Dissertation note | Improving oral drug absorption and bioavailability is a major issue with the pharmaceutical industries and a number of approaches to enhance the intestinal absorption of drugs have been taken up. Particle size reduction has been proved an important aid in improving bioavailability and drug delivery by increasing the solubility and dissolution rates of poorly soluble drugs. In this study, Diclofenac Sodium was formulated with polyethylene glycol in different ratios to examine the effect of concentration of carriers on properties of diclofenac sodium and how it enhances the aqueous solubility of drug. Diclofenac sodium and other powder mixtures were characterized by compressibility, bulk and tapped density, angle of repose, solubility and dissolution. The data on flow properties, solubility and dissolution was calculated for comparative analysis of diclofenac sodium in bulk with formulated solid dispersion. Results showed improved flow of powders and improved water solubility of drug. The solubility and dissolution data showed the better results for the formulation with code SDF2. The physicochemical characteristics of the prepared formulations were assessed by differential scanning calorimetry, Fourier transform infrared spectroscopy and scanning electron microscopy. The DSC and FTIR studies revealed that there was no interaction between drug and carriers. It was concluded that the SD prepared by solvent evaporation technique using hydrophilic polymer enhanced solubility and dissolution and hence better patient compliance and effective therapy. |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical Term | Pharmaceutics |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical Term | Pharmaceutical Sciences |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Personal name | Dr. Farzana Chowdhary |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prof. Dr. Muhammad Ashraf |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Thesis |
Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
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Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2017-05-23 | 2718-T | 2718-T | Thesis |