Evaluating The Efects Of Prebiotics In Rehabilitation Of Gut Microbiota After Antibiotic (Cephalexin) In Rats (Record no. 13543)
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| fixed length control field | 02894nam a22002057a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20170919104337.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170919b2017 xxu||||| |||| 00| 0 eng d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 2859-T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Rabia Omer (2011-VA-512) |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr. SanaullahIqbal |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluating The Efects Of Prebiotics In Rehabilitation Of Gut Microbiota After Antibiotic (Cephalexin) In Rats |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2017. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | 66p.; |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Antibiotics are widely used to kill pathogenic bacteria that have adverse effects on human health. It has been seen that these kind of drugs causes imbalance of microbes because these are not only target the pathogens but also suppressing the growth of beneficial bacteria. Beneficial bacteria such as bifidobacteria and lactobacilli species conquer many benefits for human health. That’s why there is a need to rehabilitate these valuable microorganisms. The worthwhile approach in this regard is the use of galacto-oligosaccharides(GOS). Adult male Wistar rats (n= 24) were used in present study. Rats were divided into 4 groups having 6 rats in each group. Group G1 was a control normal that was fed on a basal diet. Group G2 was treated with an antibiotic cephalexin for five days. Moreover, Group G3 wasgiven GOS as well as antibiotic. In Group G4, firstly antibiotic was given for specific duration and after that GOS was given for the rest period of time. The fecal sample were collected from rats with time interval of 0, 5 , 10 and 15day of antibiotic therapy or treatment and were analyzed for bacterial population especially Bifidobacteria, Lactobacilli, E. coli and total plate count using selective media. The results of bifidobacteria and lactobacilli of group 3 were significantly same with group 1 at 15th day and were notably higher from group 1 at 20th day. In addition the beneficial species in group 2 were decreased at 5th day that significantly different with group 1 and didn’t recover till at 20th day. The colonies of E. coli in various groupswere different at various time intervals. Moreover the results of TPC were based on the treatments. It was significantly higher in group 3 that was given antibiotic with prebiotics while it was significantly lower in group 2 as compared to normal.The data were analyzed using One way Analysis of variance (ANOVA). The group differences were compared by the Duncan’s Multiple Range Test. Differences were considered significant at P < 0.05. This study helped to turn down the side effects of antibiotic as well as maintain the normal micro-flora by rehabilitate the beneficial species such as bifidobacteria and lactobacilli and also suppressing the growth of harmful pathogens e.g. E. coli |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Food Science and Human Nutrition |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mr. Muhammad Amir Iqbal |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Sajid khan Tahir |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2017-09-19 | 2859-T | 2859-T | Thesis |