Genome Instability in Cancer Development (Record no. 1443)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02202nam a2200241 a 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 1402037635 (hardcover) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 9781402037634 (hardcover) |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 614.5999 Nigg 27639 V.570,1st 2005 Genetics |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Nigg, Erich A. |
| 245 10 - TITLE STATEMENT | |
| Title | Genome Instability in Cancer Development |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2005th ed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication | Netherlands, : |
| Name of publisher | Springer, |
| Year of publication | 2005. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | 512 p. ; |
| 490 1# - SERIES STATEMENT | |
| Series statement | Advances in experimental medicine and biology. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Cancer--Genetic aspects |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Genomics |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Medicine |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Oncology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Life sciences |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Tumors--Etiology |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Books |
| Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Source of acquisition | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| UVAS Library | UVAS Library | Genetics | 2015-05-15 | Purchase | 614.5999 Nigg 27639 V.570,1st 2005 Genetics | 27639 | Books |