Comparative Efficacy Of Tryupanocidal Drugs And Their Effects On Some Blood Parameters In Equine Trypanosomiasis (Record no. 2047)

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005 - DATE AND TIME OF LATEST TRANSACTION
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008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s1988 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 0282,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Noor Ahmed Khan
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Muhammed Sarwer Khan
245 ## - TITLE STATEMENT
Title Comparative Efficacy Of Tryupanocidal Drugs And Their Effects On Some Blood Parameters In Equine Trypanosomiasis
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 1988
502 ## - DISSERTATION NOTE
Dissertation note Trypanosomiasis causes great losses in equines, if not treated properly. This study was planned to determine the

prevalence and treatment of T.evansi infection with different drugs in equines in and around Lahore. The effect of drugs on DLC and haemoglobin was also determined. For this purpose 350 healthy and suspected horses were examined. Thirty positive cases were divided into 3 equal groups. Two groups were served with two different trials, and 3rd group was kept as untreated infected control. A 4th group was kept as non-infected and untreated control. All the animals were examined at regular intervals for the presence or absence of parasites post-treatment. The DLC and haemoglobin contents were recorded just before and on day 21 post-treatment. The data so obtained was analysed statistically and results were made as under.

1) Prevalence

Out of 350 horses, 37 were positive to T.evansi. The prevalence was 10.57 percent.

2) Efficacy

The Suramin (Naganol Bayer) was 70% Trypanocidal on day 0 and 100Z on day 10 and 21 post treatment; while the Quinapyrainine (Trypacide N & B) was 80% effective on day 5 and 100% on day 10 and 21 post treatment.

3) DLC

Harked Neutropenia with lymphocytosis was observed before tree tinent. The average values of Neutrophils were 42.5 ± 0.65.. 42.6 ± 0.61, 42.7 .± 0.65 and 61.4 .± 0.48 in the 4 groups respectively. The reduction in Neutrophils and increase in lymphocytes was 30.62% and 69.96%. On day 21 after treatment Neutrophil and lymphocyte count became 61.8 ± 0.41 and 55.1 .± 0.56 in group I and II respectively; while the group III and IV revealed no difference in their count. There was 35% increase in Eosinophils of group I, II and III before treatment, the average being 5.6 ± 0.26, 5.2 ± 0.24 and 5.4 ± 0.27 respectively: while the group IV possessed 4.00 ± 0.23% neutrophils. The eosjnophjlja tended to become normal with 29.63% decrease, average being 3.9 ± 0.4 and 3.7± 0.56 in group I and II respectively) on day 21 post-treatment; while this count remained nearly the same in group IV on same day.

The Basophil count remained unchanged before and - after treatment in all the 4 groups. The average values on day 0 were 1.7 ± 0.17, 1.5 ± 0.17, 1.2 ± 0.16 and 1. 1 ± 0. 16 and on day 21 1.6 ± 0. 16, 1.1 ± 0.16, 1.5 ± 0.17 and 1.6 ± 0.2 for group I, II, III and IV respectively.

4) Haemoglobin

There was 38. 78% decrease in haemoglobin content in infected animals. The average values raised up after treatment from 6.03 ± 0.17 and 6.21 ± 0.13 to 8.24 ± 015 and 7.22 ± 0.19 with Suramin (Naganol Bayer) and Trypacide N & B respectively. Suramin (Naganol Bayer) was significantly better than Trypacide N & B in that respect. There was 15.29% decrease in group III after 21 days. The haemoglobin values of group IV remained unchanged.

5) Side Effects

The 40% horses treated with Suramin (Naganol Bayer) revealed signs of hypersensitivity. The 50% of animals treated with Trypacide N & B developed oedemas. at the site of injection.

Note: Quinapyraroine (Trypacide N & B) was concluded to be the drug of choice for equine Trypanosomiasis.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Clinical Medicine & Surgery
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Muhammed Athar Khan
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Naeem Ullah
710 ## - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Veterinary Sciences
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-26 0282,T 0282,T Thesis


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