Bioavailability Of Gentamicin In Male Buffalo Calves (Record no. 2147)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02051nam a2200205Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20150921131819.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s1994 xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 0390,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Hasan Raza, S |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr. Muhammad Sarwar Khan |
| 245 ## - TITLE STATEMENT | |
| Title | Bioavailability Of Gentamicin In Male Buffalo Calves |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 1994 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | The bioavailability and pharmacokinetics of Gentamicin sulphate were investigated in the same 20-male buffalo calves heal thy after intravenous administration and after intramuscular administration. The blood samples were collected at various time intervals following administration of single dose of 4 mg/kg. The concentrations of Gentamicin in serum samples were determined according to the microbiological assay described by Arret (1971). The plasma concentrations of gentarnicin at different time intervals after injections were plotted on semi-logarithmic graph paper. The bioavailability and pharmacokinetics parameters were calculated according to the method described by Gibaldi (1984). Results were expressed as mean ± SD. The peak concentration of 11.273 ± 0.4976 µg/ml reached in 31.092 ± 1.217 minutes after intramuscular injection. Keeping intravenous as standard the relative bioavailability after injection was 82.5%. The half-life was 97.29 ± 5.259 minutes after I/v injection mean ± SD, volume of distribution was 202.36 ± 8.486 ml/kg/ The volume of distribution at steady stage (Vdss ) was 214.67 ± 20.99 ml/mm. The total body clearance of gentamicin was 1.7382 ± 0.0738 ml/kg. Pharmacokinetics parameters of gentamicin were seemed to be independent of rout of administration at the dosage level applied. The pharmacokinetics evaluation by compartmental method and non-compartmental method was not found significantly different. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Clinical Medicine & Surgery |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Muhammad Ashraf |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prof. Dr. Saghir |
| 710 ## - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Faculty of Veterinary Sciences |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-27 | 0390,T | 0390,T | Thesis |