Protective Effect Of Diltiazem Hydrochloride On Occurrence Of Alloxan Induced Diabetes In Rabbits (Record no. 2321)

000 -LEADER
fixed length control field 02644nam a2200193Ia 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20150918142257.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s1998 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 0577,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Azeem, M
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Dr.Muhammad Razzaq Ali
245 ## - TITLE STATEMENT
Title Protective Effect Of Diltiazem Hydrochloride On Occurrence Of Alloxan Induced Diabetes In Rabbits
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 1998
502 ## - DISSERTATION NOTE
Dissertation note An investigation was carried out to study the protective effect of calcium channel blocker i.e. diltiazem hydrochloride on occurrence of alloxan diabetes in rabbits and also to see the protective effect of a herbal mixture of medicines, i.e. Kalonji, Kasni and Maithee on occurrence of alloxan induced diabetes in rabbits.

For this purpose, 20 rabbits were randomly divided into four groups i.e. A, B, C and D, comprising 5 rabbits in each and were provided food and water libitum.

Each of the members of group A (control) were given 150 mg/kg body weight alloxan intravenously into ear vein. These animals were given food and water libitum for two days, then they were fasted over night and blood samples were collected for estimation of glucose and total protein.

The results obtained showed significant increase in blood glucose level subsequent to the administration of alloxan. There was no change observed in total protein.

The rabbits of group B were given 20 mg/kg body weight of Diltiazem hydrochloride intraperitoneally and after 15 minutes alloxan was administered intravenously. The results obtained showed significant increase in blood glucose level and no effect on total protein.

Similarly the rabbits of group 'C' were given 40 mg/kg body weight of diltiazem hydrochloride intraperitoneally and then after 15 minutes 150 mg/kg body weight of alloxan was administered intravenously into ear vein. Blood samples showed significant decrease in blood glucose level and no effect on total protein.

While rabbits of group-D were given 2 gm/kg body weight of herbal mixture orally, and then after two hours alloxan was administered intravenously. The data showed a significant rise in blood glucose level and again no effect on total protein. This showed that the herbal mixture had no protective effect.

From this result, it is conceivable that diltiazem hydrochloride showed protective effect on occurrence of alloxan induced diabetes in rabbits and there was no effect on total protein whereas the herbal mixture did not have protective effect.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Pharmaoclogy & Toxicology
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr.Haji Ahmad
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr.Muhammad Sabir
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-27 0577,T 0577,T Thesis


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