Synthesis And Evaluation Of Biological Properties Of Derivatives Of Cephalosporins (Record no. 2346)
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| 000 -LEADER | |
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| fixed length control field | 02141nam a2200193Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20150918143716.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s1999 xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 0602,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Rehmat Ullah, Major |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr.Muhammad Sabir |
| 245 ## - TITLE STATEMENT | |
| Title | Synthesis And Evaluation Of Biological Properties Of Derivatives Of Cephalosporins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 1999 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | This study was aimed at preparation and evaluation of the biological properties of cephradine. Schiff base transition metal complexes of cephradine were prepared. In the first step Schiff bases were prepared by condensation of the primary amine with a carbonyl compound. For this purpose pyridoxal HCI and salicylaldehyde were used. In the next step the prepared Schiff bases were chelated with metal salts using copper acetate and zinc acetate, here metal binds to polydenate ligands to form the ring structure, where metal is the part of the ring. In this way a three dimensional molecule was obtained which exhibited enhanced antibacterial activity in some cases and depressed activity in the others. The complexes were subjected to biological evaluation to find out the minimum lethal concentration of the new complexes and then it was compared with the parent drug. The standard organisms of S. aureus, .E.coli Pseudomonas aeruginosa and . pneumoniae were used to study the antimicrobial activity. Cephradine complexes showed a depressed activity against S. aureus, . E.coli and P . aemginosa. But the activity of CPC and CSC derivatives was found ten times enhanced against K. pneumoniae, when compared with the present drug. The haematological study revealed that the parent drug and the new derivatives did not have any deleterious effect upon the total erythrocyte count, haemoglobin concentration, leukocytic count, differential leukocytic count i.e., lymphocytes and polyrnorphs (neutrophils). Thus the new compounds were found to be as safe as the parent drug itself. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Pharmaoclogy & Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr.Haji Ahmad |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr.Muhammad Raziq Ali |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
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| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-27 | 0602,T | 0602,T | Thesis |