| 000 -LEADER |
|---|
| fixed length control field |
02352nam a2200205Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20150921132058.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150525s2002 xx 000 0 und d |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
0742,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME |
|---|
| Personal name |
khawar Qayyum |
| 110 ## - MAIN ENTRY--CORPORATE NAME |
|---|
| Location of meeting |
Prof.Dr.Muhammad Ashraf |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Effect Of Ivermetin On Liver At Therapeutic And Higher Doses In Healthy And Diseased Dogs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Year of publication |
2002 |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
The project was designed to evaluate the efficacy of ivermectin against external parasites as well as its toxicity on liver at therapeutic and higher doses in healthy and disease (positive for external parasites) dogs of local breeds. For this purpose forty dogs were selected and divided into four groups (A, B, C and D) comprising 10 dogs in each. Dogs of groups A and B were healthy while dogs of group C and D were positive for external parasites. Dogs of group A were administered ivermectin at therapeutic doses (0.2mg/kg body weight subcutaneously) while of group B were given ivermectin 10 times higher dose (2mg/kg body weight subcutaneously). Similarly dogs of group C and D positive for external parasites were given normal and higher doses of ivermectin respectively. To assess the efficacy of ivermectin, skin scrapping examination was performed before and after treatment, while to evaluate the toxicity alkaline phosphatase and alanine aminotransferase enzyme activity was measured before and after treatment. The results indicated that ivermectin was quite effective against external parasites 70% and 80% at therapeutic and higher doses respectively, but the efficacy against ticks was 100% at both the dose rates without any side effect except in one dog showing irritation at the site of injection at the higher dose of ivermectin. Liver enzyme study indicated that alkaline phosphatase was not altered significantly in diseased or healthy dogs at low or higher doses of ivermectin. Alanine aminotransferase activity was also not altered significantly in diseased as well as in healthy dogs. Therefore it is concluded that ivermectin is a safe drug for the treatment of ectoparasites in local breeds of dogs.
|
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical Term |
Department of Clinical Medicine & Surgery |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr. Asim Aslam |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr. Muhammad Sarwar Khan |
| 710 ## - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
Faculty of Veterinary Sciences |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
