Studies On Gentamicin Toxicity In Broiler Chickens (Record no. 2620)

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fixed length control field 02733nam a2200205Ia 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20150921152946.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s2004 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 0893,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Muhammad Shah Rukh
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Prof.Dr.Muhammad Ashraf
245 ## - TITLE STATEMENT
Title Studies On Gentamicin Toxicity In Broiler Chickens
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 2004
502 ## - DISSERTATION NOTE
Dissertation note This project was designed to evaluate the toxic effects of gentamicin sulphate at different dosage levels in broiler chicks. The experiment was conducted in two phases. During phase I one hundred broiler chicks were divided into A,B, C and D groups having twenty five birds in each and were injected gantamicin sulphate in the form of gentalin 5% intramuscularly at the rate of 5mg/kg, lOmg/ kg, 20mg /kg in groups A,B and C twice daily for four days respectively while group D kept as control. During phase II twenty five chicks were divided into groups E,F,G,H and I having five birds in each. Birds in groups E and F were injected gentalin 5% intramuscularly at the rate of 40mg/kg and 80 mg/kg while gantamicin sulphate injected in the form of Aagent 10% at the rate of 40 mg / kg and 80 mg/kg to groups G and H twice daily for four days respectively and the birds of I group were kept as control.

Blood samples (3m1) were collected from all medicated and un-medicated groups before and after medication on different days and serum was separated for the measurement of different biochemical parameters. Post-mortem examination of all birds were performed at the end of experiment. Post-mortem examination revealed no abnormality in any bird during phase I (normal organs) while during phase II abnormalities such as congestion, inflammation of the kidney and necrosis, discoloured livers were recorded except control group. Six birds died during experiment in phase 11(2/10 at 40mg/kg and 4/10 at 80mg/kg dose). The mortality rates at 40 mg/kg and 80 mg/kg were 20 and 40% respectively. An increase in Aspartate amino Transferase was observed in medicated birds during phase I while a significant increase in Aspartate amino Transferase, Alanine amino Transferase, uric acid and creatinine were recorded in medicated birds during phase II. From this study it is concluded that broiler birds tolerated gentamicin upto 20mg/kg while acute toxic effects at the dose of 40mg/kg and 80mg/kg of gentamicin were recorded in broiler chicks. No sign of visceral gout were recorded in any bird. There was no difference in the toxicity of two different preparations of gentaniicin.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Physiology
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr. Muhammad Omer
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Prof. Dr.
710 ## - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Biosciences
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-28 0893,T 0893,T Thesis


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