| 000 -LEADER |
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| fixed length control field |
02375nam a2200193Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20151001132805.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150525s2009 xx 000 0 und d |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
1071,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME |
|---|
| Personal name |
Sidra Abdil Rahman |
| 110 ## - MAIN ENTRY--CORPORATE NAME |
|---|
| Location of meeting |
Prof.Dr.Muhammad Ashraf |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Effect Of Total Particulate Matter From Commercial Cigrettes On Wound Healing In Mice |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Year of publication |
2009 |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
ACigarette smoking is considered as the most important cause of death in developed countries. Wound healing in the skin is a multifarious orchestration of cellular processes and cigarette smoking may grounds for delayed wound healing. The aim of this study was to investigate, the plausible association between exposures of cigarette total particulate matter (TPM) on wound healing. The invivo mice model of wound healing was customized for determinenation of assorted events of wound healing. A total of 49 adult mice separated in seven groups and kept under standard conditions of ventilation and temperature. Four brands of commercially available cigarette were selected for the current study. All the treated animals were exposed to TPM ointment for 12 days. A highly considerable diminution in wound closure was pragmatic among all TPM treated groups from day 6 to day 8 post-wounding. Histological investigations unveiled a noteworthy impede in the outcome of re-epithelialization, dermal matrix regeneration and maturation of collagen bundles among all TPM-exposed wounds. Delayed commencement of neovascularization was pragmatic among TPM treated groups, at day 12 post wounding. Quantification was done with the help of scan probing image processing software and image processing system. Abbot curve, angular spectrum and different other parameters of 3D surface behavior of wounds revealed a very highly significant reduction in angiogenesis at day 6 and day 8 post-wounding, which points that application of TPM instigate extensive delay in trigging the progression of angiogenesis, resulting delayed onset of wound healing. These annotations validate the damaging effects of TPM on the healing of wounds and excessive use of TPM may lead to the production of chronic wounds and oral ulcers.
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| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical Term |
Department of Pharmaoclogy & Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr.Sheryar Afzal |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Prof.Dr.Zafar Iqbal Ch. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
