Quality Evaluation Of Different Brands Of Ceftriaxone (Record no. 3168)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02271nam a2200193Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20151006125921.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s2012xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 1462,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Sana Tariq |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Prof. Dr. Muhammad Ashraf |
| 245 ## - TITLE STATEMENT | |
| Title | Quality Evaluation Of Different Brands Of Ceftriaxone |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2012 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | This study was designed to determine the physicochemical equivalence of selected brands of ceftriaxone sodium registered with the ministry of health government of Islamic republic of Pakistan. Out of 9 selected brands 3 were of lowest price distribution class, 3 from the intermediate price distribution class and remaining three from the highest price distribution class. For quality evaluation 3 parameters were selected which were physical, chemical and microbial. Physical characters analyzed were general appearance, pH, solubility and moisture content. Characters which determine the chemical equivalence were assay of active ingredient and percentage of impurities present in powdered drug. Both these parameters were quantified chromatographically using high pressure liquid chromatography. Clinical efficacy of selected brands of this valuable antibiotic was accessed by determining the minimal inhibitory concentrations against Staphylococcus aureus, Salmonella typhi, Klebsiella pneumonia and Escherichia coli. Statistically all brands were significantly different from one another but all the parameters taken as quality indicators showed results within the range specified by united state pharmacopoeia. None of selected brands of ceftriaxone sodium were found to be counterfeit or even substandard. Irrespective of difference in price, no visible variation was found among different quality assessment parameters, all samples showed compliance with the international pharmacopoeial standards. Through this study it can be concluded that the quality of ceftriaxone in Pakistan is well regulated, all the registered brands are up to the mark and irrespective of variation in price there is no variation in the quality of brands. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Pharmaoclogy & Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Muhammad Adil Rasheed |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miss Huma |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-29 | 1462,T | 1462,T | Thesis |