Variation In The Non Structural Nd3 Gene Of Hepatitis C Viruses Isolated From Local Hospital Samples (Record no. 3211)

000 -LEADER
fixed length control field 01878nam a2200193Ia 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20151006131843.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s2011 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 1507,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Muzna Rana
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Dr. Asif Nadeem
245 ## - TITLE STATEMENT
Title Variation In The Non Structural Nd3 Gene Of Hepatitis C Viruses Isolated From Local Hospital Samples
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 2011
502 ## - DISSERTATION NOTE
Dissertation note Hepatic C virus (HCV) infects approximately 4% of the population worldwide. HCV establishes a chronic infection of the liver that causes cirrhosis and can lead to the development of hepatocellular carcinoma. HCV is transmitted exclusively through direct blood-to-blood contacts between humans. Current drug therapies for HCV infection often fail to resolve viral infection; therefore, new approaches for treating HCV infection are crucial in controlling chronic HCV infection. The viral protease NS3 has been identified as an attractive target for anti-HCV drugs, because its activity is indispensable for processing many of the NS proteins of HCV. Although the NS3 helicase is a potentially attractive target for anti-HCV drugs, no helicase inhibitors have yet entered clinical trials. In this research we are going to isolate the NS3 region of HCV genome, from different HCV positive patients with the help of RT PCR. Then sequence these, and observe similarities in these sequences. The main objective of the present study is to determine variation in the non structural gene NS3 of hepatitis C viruses isolated from patients suffering from hepatitis and reporting to local hospitals. The ultimate objective would be to utilize this data generated in this study attempting to prepare vaccine against this virus.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Institute of Biochemistry & Biotechnology
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr. Abu Saeed
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mrs. Saeeda Awais
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-29 1507,T 1507,T Thesis


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