Antibacterial And Cytotoxic Evaluation Of Different Extracts Of Glycyrrhiza Glabra (Liquorice) Roots Against Common Poultry Pathogens (Record no. 8700)
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| 000 -LEADER | |
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| fixed length control field | 02968nam a22002057a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160711130344.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160711b2015 xxu||||| |||| 00| 0 eng d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 2442-T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Javaria Arooj (2013-VA-596) |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Dr. Muhammad Ovais Omer |
| 245 ## - TITLE STATEMENT | |
| Title | Antibacterial And Cytotoxic Evaluation Of Different Extracts Of Glycyrrhiza Glabra (Liquorice) Roots Against Common Poultry Pathogens |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | 100p.; |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Majority of antibacterial drugs in clinical use are derived from natural origin. Hence, the present study is designed for antibacterial and cytotoxic evaluation of different extracts of Glycyrrhiza glabra Linn. roots against common poultry pathogens. The four sequential i.e. hexane, chloroform, ethanol and aqueous extracts of Glycyrrhiza glabra Linn. roots were prepared by soxhlet extraction. Antibacterial activity of these extracts was determined by agar well diffusion method against Staphylococcus aureus, Clostridium perfringens type A, Escherichia coli, Salmonella enterica and Haemophilus paragallinarum. Zone of inhibitions were determined by well diffusion method. MICs of plant extracts were determined by micro broth dilution method. Cytotoxic activity was evaluated by applying MTT assay on Vero cell lines. The zone of inhibitions showed by hexane, chloroform and ethanolic extracts of Glycyrrhiza glabra Linn. roots against Staphylococcus. aureus were10.3mm, 13.0mm, 11.6mm; against Clostridium perfringens type A were20.0mm, 17.3mm, 17.3mm; against Escherichia coli were11.6mm, 19.3mm, 16.0mm; against Salmonella enterica were13.6mm, 14.0mm,14.0mm; against Haemophillus paragallinarum were13.0mm, 15.0mm, 17.0mm respectively. Aqueous extract showed no zone of inhibition against any test bacteria. MICs values of hexane, chloroform and ethanolic extracts of Glycyrrhiza glabra Linn. roots against Staphylococcu aureus were 13.0μg/ml, 312.5μg/ml and 104.1μg/ml; against Clostridium perfringens type A were 9.766μg/ml, 71.61μg/ml and 520.8μg/ml; against Escherichia coli were 65.1μg/ml, 52.8μg/ml and 156.25μg/ml; against Salmonella enterica were Summary 86 19.5μg/ml, 130.2μg/ml and 78.12μg/ml; against Haemophillus paragallinarum were 91.1μg/ml, 29.2μg/ml and 130.2μg/ml respectively. Aqueous extract showed no MIC value as no zone of inhibitions wereobserved against them. Hexane extract of Glycyrrhiza glabra Linn. roots was cytotoxic at concentration ≥ 650μg/ml, chloroform extract at concentration ≥ 2500μg/ml and ethanolic extract was not cytotoxic to cell. The indigenous plant Glycyrrhiza glabra Linn. roots have antibacterial activity against common poultry pathogens and helpful to develop new drug from plant origin. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Pharmacology and Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Muhammad Adil Rasheed |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prof. Dr. Aftab Ahmad Anjum |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
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| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2016-07-11 | 2442-T | 2442-T | Thesis |