| 000 -LEADER |
|---|
| fixed length control field |
02579nam a22002057a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20160711133500.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160711b2015 xxu||||| |||| 00| 0 eng d |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
2448-T |
| 100 ## - MAIN ENTRY--AUTHOR NAME |
|---|
| Personal name |
Saba Shahbaz (2013-VA-852) |
| 110 ## - MAIN ENTRY--CORPORATE NAME |
|---|
| Location of meeting |
Dr. Muhammad Ovais Omer |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Antibacterial Activity Of Piroxicam And Ketorolac Alone And In Combination With Antibiotics Against Bacterial Isolates |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Year of publication |
2015. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Number of Pages |
76p.; |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Antibiotic resistance has become a global public health problem due to the excessive and indiscriminate use of antibiotics, which has resulted in many emerging multidrug-resistant microorganisms. This study is designed for the evaluation of different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline by using broth dilution method.Different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline were checked for antibacterial activity against Staphylococcusaureus and Escherichia coli.The isolates were obtained from Quality Operations Laboratory. The pathogens were tested for their sensitivity to amoxicillin and tigecycline. The sensitivity was checked by broth/tube dilution method. Dilutions were prepared by two fold dilution method.Collected data was analyzed by using statistic package for social sciences (SPSS, windows version, Chicago, IL, USA). Analysis of Variance (ANOVA) and descriptive statistics was applied.This work is designed to observe the effects of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline against bacterial pathogens to improve the quality of life of patients and will minimize the chances of infections.Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was determined by broth dilution method. The results suggested that NSAIDs enhanced the antibacterial effect when combined with these antibiotics. Combination of amoxicillin with piroxicam (9.76µg/ml+80µg/ml), and tigecycline in combination with ketorolac (0.156µg/ml+20µg/ml) was effective against Staphylococcusaureus. The combination of amoxicillin with piroxicam (9.76µg/ml+20µg/ml), amoxicillin with ketorolac (4.88µg/ml+20µg/ml), tigecycline with piroxicam (0.3125µg/ml +10µg/ml), tigecycline with ketorolac (0.312µg/ml+20µg/ml) showed efficacy against Escherichia coli. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical Term |
Department of Pharmacology and Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr. Muhammad Adil Rasheed |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr. Imran Altaf |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
