The present research project was designed to study the effect of three routinely used
pre anaesthetic (alpha-2 adrenergic agonists) drugs xylazine (xylaz; 20 mg/ml, farvet, Holland)
and medetomidine (doiter, 1 mg/ml ; Orion pharma, finland), diazepam(Valium 0.25 mg/kg) and
propofol (pofol, 10 mg/ml ;Dongkook pharma, korea) anaesthesia in male dogs and castration
surgery was performed using pre scrotal approach. The effect of these sedative and anaesthetic
agents was studied at physical (temperature, pulse, and respiration), sedative (palpebral effect),
analgesic (tail pinch, toe pinch reflex), liver function (ALT, AST, and ALP), renal functions
(serum creatinine, BUN) and haematological (RBC, WBC, Hb) parameters. A total number of
twelve (12) dogs (mix breed) clinical cases were selected. These dogs were subjected into three
groups (A, B , C) each comprising four (4) dogs. Different drugs combination was administered
in each group of dogs. Three different drug combinations are;
Group A .Xylazine-Propofol
Group B. Diazepam-Propofol
Group C. Medetomidine-Propofol
Blood samples were taken at four different intervals like 0 minutes, 30 minutes, 60
minutes and after 24 hours in EDTA coated vacutainer for studying haematological parameters
and in lithium heparin vacutainer for evaluating biochemical parameters.
Results revealed that both sedative and anaesthetic agents produce slight non-significant changes
in liver enzymes but in case of renal function test, medetomidine-propofol produce significant
Summary
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changes in serum creatinine and xylazine-propofol, and diazepam-propofol produce significant
changes in the values of blood urea nitrogen. Coming towards haematology, white blood cells
increase significantly in diazepam-propofol receiving group. The results of the present research
study were mostly similar with the findings of other scientists. The results of present project
were analysed by ANOVA followed by Turkey honestly significant difference (HSD) test.
Conclusion
The result of present project will prove fruitful for veterinary practioners for selectin
anaesthesia protocol for patients suffering from hepatitis or other liver, renal and haematological
problems and would be productive to solve the problems of anaesthetists who are actively
engaged in canine practice all over the world. On the basis of findings of this study it is
concluded that medetomidine-propofol combination gives better results.