Comparison Of Response Of Oral Versus Injectible Vitamin D In Children Having Rickets
By: Rabia Mazari (2014-VA-909)
| Dr. Waqas Ahmad.
Contributor(s): Dr. Huma Imran | Dr. Muhammad Nasir | Dr. Muhammad Bilal.
Material type: 
BookPublisher: 2016Description: 59p.Subject(s): food Sciences And Human NutritionDDC classification: 2742-T Dissertation note: Nutritional rickets is a common problem in Pakistan as highlighted in different studies. Nutritional rickets is a childhood bone disorder in which bones become soften and deformity occurs. The main cause of this rickets is lack of vitamin D. In Pakistan, the prevalence of vitamin D deficiency among children has been reported as 40%.
Methodology consist of division of 2 groups (oral, injectable).A specific amount of doses (200,000 i.u) was given to both groups for about 3 months. All children were followed up for two more visits on thirty and ninety day. In the follow-up visits the children were subjected to clinical, biochemical and radiological examination and their findings were recorded.
Anthropometric measurements included wide wrist frontal bossing, and head circumference etc. Biochemical findings included different test for serum calcium level, serum phosphorous level, serum alkaline phosphatase and 25 dehydroxyvitamin D. Radiological examination was consisting of X-Ray reports of wrist and knee.
Analysis of Variance (ANOVA) was used. Means were compared for significance
through LSD. Level of significance was defined as ≤ 0.05.Cohort software version Costat 6.303 was used for all statistical analysis.
There were no undesirable side effects observed in either group of children and both oral and injectable forms of treatment were well-tolerated. The injectable route was little bit highly efficient than oral one as expected. But this difference in efficiency is not that much significant.
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|---|---|---|---|---|---|---|---|
Thesis
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UVAS Library Thesis Section | Veterinary Science | 2742-T (Browse shelf) | Available | 2742-T |
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Nutritional rickets is a common problem in Pakistan as highlighted in different studies. Nutritional rickets is a childhood bone disorder in which bones become soften and deformity occurs. The main cause of this rickets is lack of vitamin D. In Pakistan, the prevalence of vitamin D deficiency among children has been reported as 40%.
Methodology consist of division of 2 groups (oral, injectable).A specific amount of doses (200,000 i.u) was given to both groups for about 3 months. All children were followed up for two more visits on thirty and ninety day. In the follow-up visits the children were subjected to clinical, biochemical and radiological examination and their findings were recorded.
Anthropometric measurements included wide wrist frontal bossing, and head circumference etc. Biochemical findings included different test for serum calcium level, serum phosphorous level, serum alkaline phosphatase and 25 dehydroxyvitamin D. Radiological examination was consisting of X-Ray reports of wrist and knee.
Analysis of Variance (ANOVA) was used. Means were compared for significance
through LSD. Level of significance was defined as ≤ 0.05.Cohort software version Costat 6.303 was used for all statistical analysis.
There were no undesirable side effects observed in either group of children and both oral and injectable forms of treatment were well-tolerated. The injectable route was little bit highly efficient than oral one as expected. But this difference in efficiency is not that much significant.
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