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Anthelmintic Activity Of Euphorbia Plant Against Gastrointestinal (Git) Nematodes In Goats In District Killa Saifullah, Balochistan

By: Wseem Khan (2008-VA-214) | Dr. Muhammad Lateef.
Contributor(s): Dr. Saadullah Jan | Dr. Haroon Akbar | Dr. Muhammad Avais.
Material type: materialTypeLabelBookPublisher: 2016Description: 57p.Subject(s): ParasitologyDDC classification: 2769-T Dissertation note: With the passage of each day, the parasites are becoming more and more drug resistant thus reducing the options for their treatment. There is a need to explore herbal products having anthelmintic activity. The aim of this study was be to evaluate therapeutic efficacy of Euphorbia plant against gastrointestinal nematodes of goats. It is documented that Euphorbia plant extracts have efficacy against GIT nematodes in goats. (CP) and (CME) of the plants were used to evaluate the effect of the plant on GIT nematode in goats. Eighty goats positive for GIT nematodes were selected for GIT nematodes in vivo study of the plant and Albendazole. Goats were divided into 8 groups and each group containing 10 goats. Animals in group A were positive Control Untreated Group, in group B that is B1, B2 and B3 were treated with 1g/kg b.wt. CP of Euphorbia 2g/kg b.wt. CP of Euphorbia and 3g/kg b.wt. CP of Euphorbia respectively. Animals in group C that is C1, C2 and C3 were treated with CME of Euphorbia. At the equivalent dose rate of 1g/kg b.wt CP, CME of Euphorbia at the equivalent dose rate of 2g/kg b.wt CP and CME of Euphorbia at the equivalent dose rate of 3g/kg b.wt CP. Group D were treated with Albendazole at recommended dose rate of 3.8mg/kg body weight. Animals were treated on day zero with crude methyl extract of Euphorbia plant, crude powder of Euphorbia plant, and Albendazole. Sampling was done on day 0 pre-treatment 7, 14 and 21 post-treatment to determine eggs per gram (EPG) of faeces. Data was tabulated and subjected to SPSS and one way ANOVA was performed to find out treatment differences. Potential anthelmintic efficacy of Euphorbia plant against GIT nematodes of goats was a good herbal alternate for treatment of GIT nematode worm infections. Albendazole gave the best results in the in-vivo drug trial. The efficacy of the drug was 99.26%. This efficacy of 99.26% showed by animals in group D was highest in all treated groups. The effect of Albendazole at 21st day post treatment was significantly higher (P<0.05) than other groups treated with Euphorbia plant preparations. Crude powder of Euphorbia was highly effective as (P < 0.05) compared to the untreated control group of animals. The crude powder showed dose and time dependent decline in EPG of the nematodes infested animals. Highest efficacy was shown by the dose rate of 3g/kg body weight monitored for 21 days post treatment. The efficacy of crude powder 1g/kg body weight, 2g/kg body weight and 3g/kg body weight was 17.86%, 20.34% and 36.24% respectively. Highest efficacy was shown by crude methyl extract of the plant given orally at the dose rate equivalent to 3g/kg body weight of the animal. The efficacy of the CME of plant was 53.96% at 21st day post treatment. The old-fashioned remedy used for the cure of helminthes Euphrbia an herbal medicinal plant exhibit the anthelmintic activity against gastrointestinal nematodes. It may be suggested that the herbal plants used traditionally as curative agent should be tested out extensively for their efficacy against GIT nematodes. Further studies are required to be carried out for the Euphorbia plant and identification of active principles of the plant and toxicity studies.
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With the passage of each day, the parasites are becoming more and more drug resistant thus reducing the options for their treatment. There is a need to explore herbal products having anthelmintic activity. The aim of this study was be to evaluate therapeutic efficacy of Euphorbia plant against gastrointestinal nematodes of goats. It is documented that Euphorbia plant extracts have efficacy against GIT nematodes in goats. (CP) and (CME) of the plants were used to evaluate the effect of the plant on GIT nematode in goats. Eighty goats positive for GIT nematodes were selected for GIT nematodes in vivo study of the plant and Albendazole. Goats were divided into 8 groups and each group containing 10 goats. Animals in group A were positive Control Untreated Group, in group B that is B1, B2 and B3 were treated with 1g/kg b.wt. CP of Euphorbia 2g/kg b.wt. CP of Euphorbia and 3g/kg b.wt. CP of Euphorbia respectively. Animals in group C that is C1, C2 and C3 were treated with CME of Euphorbia. At the equivalent dose rate of 1g/kg b.wt CP, CME of Euphorbia at the equivalent dose rate of 2g/kg b.wt CP and CME of Euphorbia at the equivalent dose rate of 3g/kg b.wt CP. Group D were treated with Albendazole at recommended dose rate of 3.8mg/kg body weight. Animals were treated on day zero with crude methyl extract of Euphorbia plant, crude powder of Euphorbia plant, and Albendazole. Sampling was done on day 0 pre-treatment 7, 14 and 21 post-treatment to determine eggs per gram (EPG) of faeces. Data was tabulated and subjected to SPSS and one way ANOVA was performed to find out treatment differences. Potential anthelmintic efficacy of Euphorbia plant against GIT nematodes of goats was a good herbal alternate for treatment of GIT nematode worm infections. Albendazole gave the best results in the in-vivo drug trial. The efficacy of the drug was 99.26%. This efficacy of 99.26% showed by animals in group D was highest in all treated groups. The effect of Albendazole at 21st day post treatment was significantly higher (P<0.05) than other groups treated with Euphorbia plant preparations. Crude powder of Euphorbia was highly effective as (P < 0.05) compared to the untreated control group of animals. The crude powder showed dose and time dependent decline in EPG of the nematodes infested animals. Highest efficacy was shown by the dose rate of 3g/kg body weight monitored for 21 days post treatment. The efficacy of crude powder 1g/kg body weight, 2g/kg body weight and 3g/kg body weight was 17.86%, 20.34% and 36.24% respectively. Highest efficacy was shown by crude methyl extract of the plant given orally at the dose rate equivalent to 3g/kg body weight of the animal. The efficacy of the CME of plant was 53.96% at 21st day post treatment. The old-fashioned remedy used for the cure of helminthes Euphrbia an herbal medicinal plant exhibit the anthelmintic activity against gastrointestinal nematodes. It may be suggested that the herbal plants used traditionally as curative agent should be tested out extensively for their efficacy against GIT nematodes. Further studies are required to be carried out for the Euphorbia plant and identification of active principles of the plant and toxicity studies.

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