Comparative Efficacy Of Prazequantel, Niclosamide And Pumpkin Seeds Against Dipylidium Caninum In Dogs
By: Ayesha Arif (2015-VA-22)
| Dr. Asim Khalid Mahmood.
Contributor(s): Dr. Uzma Farid Durrani.
Material type: 
BookPublisher: 2017Description: 42P.Subject(s): Pet Animal PracticesDDC classification: 2856-T Dissertation note: Dypilidium caninum is a hermaphrodite Cestode (flatworm) consisting of a scolex, neck region and repeating segments and lacking mouth, intestine and body cavity. It has an indirect life cycle. The adult form of the tapeworm is acquired by definitive host through the ingestion of intermediate host which contains the larval metacestode stage. The major aftermath of such infections is the shedding of eggs and proglottids. It is a serious economic and zoonotic health threat. Life-threatening disease in humans, dogs and cats can be resulted by the presence of the of tapeworms immature (metacestode) stages occurring in various tissues.
The dogs clinically suspected for Dipylidium caninum and dogs having flea infestation were subjected to fecal analysis/EPG for D. caninum. Thirty dogs positive for D. caninum were divided randomly into 3 groups of 10 i.e. A, B and C. The dogs in group A were treated with praziquantel at the dose rate of 5 mg/kg orally while the animal in group B were given niclosmiode at the dose rate of 100 mg/kg per oral. The members in the group C were given pumpkin seeds powder at the dose rate of 5 gram orally.
The fecal samples from dogs in each group were collected at day 0 (pretreatment) and then at day 7, 14 and 21 (post treatment). Standard fecal flotation technique was performed for identification of Dipylidium caninum eggs using saturated salt solution. McMaster counting chamber was used for the counting of eggs.
The study results were analyzed using one way ANOVA on SPSS version 17.0. The results showed that in a post-treatment sampling of group A, the EPG count was significantly
Summary
37
reduced. Group B smplings also showed a good reduction in EPG but with the second dose whereas group C results were unsatisfactory.
On the basis of the results of this study it was concluded that Praziquantel is much more effective against Dypilidium caninum as compared to Niclosamide and pumpkin seeds, but high cost and no availability in Pakistan makes it difficult to be effectively used against Dypilidium caninum while niclosaamide is easily available and low in price. Niclosamide is effective against Dypilidium caninum but not up to the extent of praziquantel. Pumpkin seeds have poor effect on Dypilidium caninum
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2856-T (Browse shelf) | Available | 2856-T |
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Dypilidium caninum is a hermaphrodite Cestode (flatworm) consisting of a scolex, neck region and repeating segments and lacking mouth, intestine and body cavity. It has an indirect life cycle. The adult form of the tapeworm is acquired by definitive host through the ingestion of intermediate host which contains the larval metacestode stage. The major aftermath of such infections is the shedding of eggs and proglottids. It is a serious economic and zoonotic health threat. Life-threatening disease in humans, dogs and cats can be resulted by the presence of the of tapeworms immature (metacestode) stages occurring in various tissues.
The dogs clinically suspected for Dipylidium caninum and dogs having flea infestation were subjected to fecal analysis/EPG for D. caninum. Thirty dogs positive for D. caninum were divided randomly into 3 groups of 10 i.e. A, B and C. The dogs in group A were treated with praziquantel at the dose rate of 5 mg/kg orally while the animal in group B were given niclosmiode at the dose rate of 100 mg/kg per oral. The members in the group C were given pumpkin seeds powder at the dose rate of 5 gram orally.
The fecal samples from dogs in each group were collected at day 0 (pretreatment) and then at day 7, 14 and 21 (post treatment). Standard fecal flotation technique was performed for identification of Dipylidium caninum eggs using saturated salt solution. McMaster counting chamber was used for the counting of eggs.
The study results were analyzed using one way ANOVA on SPSS version 17.0. The results showed that in a post-treatment sampling of group A, the EPG count was significantly
Summary
37
reduced. Group B smplings also showed a good reduction in EPG but with the second dose whereas group C results were unsatisfactory.
On the basis of the results of this study it was concluded that Praziquantel is much more effective against Dypilidium caninum as compared to Niclosamide and pumpkin seeds, but high cost and no availability in Pakistan makes it difficult to be effectively used against Dypilidium caninum while niclosaamide is easily available and low in price. Niclosamide is effective against Dypilidium caninum but not up to the extent of praziquantel. Pumpkin seeds have poor effect on Dypilidium caninum
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