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A Study On The Effect Of Insecticide On Various Organs & Blood Parameters Of Poultry

By: Razzaq, A | Manzoor Ahmed Basra.
Contributor(s): Muhammed | Tufail Ahmed Khan | Faculty of Veterinary Sciences.
Material type: materialTypeLabelBookPublisher: 1991Subject(s): Department of PathologyDDC classification: 0226,T Dissertation note: The investigation was conducted to study the effects of organochiorine insecticide (BHC) on the hematology and liver, kidney and spleen in chickens. One hundred day-old broiler chicks were reared upto two weeks of age , then they were divided into four groups i.e. A, B, C and D (25 chicks in each group). Group A was maintained on a feed containing 100 mg BHC/kg feed. Group B was given a water contaminated with BHC at a dose rate of 100 mg/liter. Group C was reared on a litter which was sprayed with 0.65% BHC. 'ihe litter treatment was repeated at an interval of seven days. Group D was kept as control. All groups were kept under close observation for the development of signs and symptoms of BIIC toxicity. The blood from 5 chicks in each group was collected by slaughtering at the age of 14 days, 21 days, 28 days, 35 days and 42 days. From the collected blood haematologicai alterations (TLC, TEC, DLC, PCV and Hb estimation) were studied and pathological changes in spleen, liver and kidney were compared with the control group. flefore slaughtering the weight of the birds were also taken. Weight of the birds was recorded before slaughtering, there was a significant decrease in weight in groups A, B and C as compared to control group D and there was significant increase between 21-35 days, 21-35 days and 28-42 days. Antemortem symptoms were recorded throughout the experiment and observed that feed intake of the treated groups was decreased, growth was retarded significantly. The treated birds were reluctant to move, hypersensitive, dull and depressed with ruffled feathers In postmortem examination the main necropsy findings were small hemorrhages throughout the body muscles, hepatomegaly and swollen kidneys in groups A and B. The muscular hemorrhages were not recorded in group C. The main histopathological lesions of liver and kidney included vascular congestion, cloudy swelling, vacuolization, hemorrhages, leukocytic infiltration and necrosis. There were no microscopic changes in spleen of groups A and B after 21 and 28 days, but in groups A and B after 35 and 42 days vascular congestion, hemorrhages and necrosis were observed. Haematologlcal alterations were studied in all the three treated groups A, B, C and control group D. There was no significant difference found in erythrocytlc count, hemoglobin estimation and packed cell volume amongst all the groups, at all the ages. The total leukocytic count showed a significant increase in groups A, B and C as compared to control group D and there wa also a significant increase between 21-28 days, 21-35 days and 21-42 days in groups A, B and C. The differential leukocytic count showed a significant decrease in lymphocytes and eosinophils in all the three groups i.e. A, B and C throughout the treatment while heterophils and monocytes increased significantly in all three treated groups as compared to control group D, but there was no change in basophils.
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The investigation was conducted to study the effects of organochiorine insecticide (BHC) on the hematology and liver, kidney and spleen in chickens.

One hundred day-old broiler chicks were reared upto two weeks of age , then they were divided into four groups i.e. A, B, C and D (25 chicks in each group). Group A was maintained on a feed containing 100 mg BHC/kg feed. Group B was given a water contaminated with BHC at a dose rate of 100 mg/liter. Group C was reared on a litter which was sprayed with 0.65% BHC. 'ihe litter treatment was repeated at an interval of seven days. Group D was kept as control. All groups were kept under close observation for the development of signs and symptoms of BIIC toxicity. The blood from 5 chicks in each group was collected by slaughtering at

the age of 14 days, 21 days, 28 days, 35 days and 42 days. From the collected blood haematologicai alterations (TLC, TEC, DLC, PCV and Hb estimation) were studied and pathological changes in spleen, liver and kidney were compared with the control group. flefore slaughtering the weight of the birds were also taken.

Weight of the birds was recorded before slaughtering, there was a significant decrease in weight in groups A, B and C as compared to control group D and there was significant increase between 21-35 days, 21-35 days and 28-42 days.

Antemortem symptoms were recorded throughout the experiment and observed that feed intake of the treated groups was decreased, growth was retarded significantly. The treated birds were reluctant to move, hypersensitive, dull and depressed with ruffled feathers

In postmortem examination the main necropsy findings were small hemorrhages throughout the body muscles, hepatomegaly and swollen kidneys in groups A and B. The muscular hemorrhages were not recorded in group C.

The main histopathological lesions of liver and kidney included vascular congestion, cloudy swelling, vacuolization, hemorrhages, leukocytic infiltration and necrosis. There were no microscopic changes in spleen of groups A and B after 21 and 28 days, but in groups A and B after 35 and 42 days vascular congestion, hemorrhages and necrosis were observed.

Haematologlcal alterations were studied in all the three treated groups A, B, C and control group

D. There was no significant difference found in erythrocytlc count, hemoglobin estimation and packed cell volume amongst all the groups, at all the ages. The total leukocytic count showed a significant increase in groups A, B and C as compared to control group D and there wa also a significant increase between 21-28 days, 21-35 days and 21-42 days in groups A, B and C. The differential leukocytic count showed a significant decrease in lymphocytes and eosinophils in all the three groups i.e. A, B and C throughout the treatment while heterophils and monocytes increased significantly in all three treated groups as compared to control group D, but there was no change in basophils.

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