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Comparative Efficacy Of Tryupanocidal Drugs And Their Effects On Some Blood Parameters In Equine Trypanosomiasis

By: Noor Ahmed Khan | Muhammed Sarwer Khan.
Contributor(s): Muhammed Athar Khan | Naeem Ullah | Faculty of Veterinary Sciences.
Material type: materialTypeLabelBookPublisher: 1988Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 0282,T Dissertation note: Trypanosomiasis causes great losses in equines, if not treated properly. This study was planned to determine the prevalence and treatment of T.evansi infection with different drugs in equines in and around Lahore. The effect of drugs on DLC and haemoglobin was also determined. For this purpose 350 healthy and suspected horses were examined. Thirty positive cases were divided into 3 equal groups. Two groups were served with two different trials, and 3rd group was kept as untreated infected control. A 4th group was kept as non-infected and untreated control. All the animals were examined at regular intervals for the presence or absence of parasites post-treatment. The DLC and haemoglobin contents were recorded just before and on day 21 post-treatment. The data so obtained was analysed statistically and results were made as under. 1) Prevalence Out of 350 horses, 37 were positive to T.evansi. The prevalence was 10.57 percent. 2) Efficacy The Suramin (Naganol Bayer) was 70% Trypanocidal on day 0 and 100Z on day 10 and 21 post treatment; while the Quinapyrainine (Trypacide N & B) was 80% effective on day 5 and 100% on day 10 and 21 post treatment. 3) DLC Harked Neutropenia with lymphocytosis was observed before tree tinent. The average values of Neutrophils were 42.5 ± 0.65.. 42.6 ± 0.61, 42.7 .± 0.65 and 61.4 .± 0.48 in the 4 groups respectively. The reduction in Neutrophils and increase in lymphocytes was 30.62% and 69.96%. On day 21 after treatment Neutrophil and lymphocyte count became 61.8 ± 0.41 and 55.1 .± 0.56 in group I and II respectively; while the group III and IV revealed no difference in their count. There was 35% increase in Eosinophils of group I, II and III before treatment, the average being 5.6 ± 0.26, 5.2 ± 0.24 and 5.4 ± 0.27 respectively: while the group IV possessed 4.00 ± 0.23% neutrophils. The eosjnophjlja tended to become normal with 29.63% decrease, average being 3.9 ± 0.4 and 3.7± 0.56 in group I and II respectively) on day 21 post-treatment; while this count remained nearly the same in group IV on same day. The Basophil count remained unchanged before and - after treatment in all the 4 groups. The average values on day 0 were 1.7 ± 0.17, 1.5 ± 0.17, 1.2 ± 0.16 and 1. 1 ± 0. 16 and on day 21 1.6 ± 0. 16, 1.1 ± 0.16, 1.5 ± 0.17 and 1.6 ± 0.2 for group I, II, III and IV respectively. 4) Haemoglobin There was 38. 78% decrease in haemoglobin content in infected animals. The average values raised up after treatment from 6.03 ± 0.17 and 6.21 ± 0.13 to 8.24 ± 015 and 7.22 ± 0.19 with Suramin (Naganol Bayer) and Trypacide N & B respectively. Suramin (Naganol Bayer) was significantly better than Trypacide N & B in that respect. There was 15.29% decrease in group III after 21 days. The haemoglobin values of group IV remained unchanged. 5) Side Effects The 40% horses treated with Suramin (Naganol Bayer) revealed signs of hypersensitivity. The 50% of animals treated with Trypacide N & B developed oedemas. at the site of injection. Note: Quinapyraroine (Trypacide N & B) was concluded to be the drug of choice for equine Trypanosomiasis.
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Trypanosomiasis causes great losses in equines, if not treated properly. This study was planned to determine the

prevalence and treatment of T.evansi infection with different drugs in equines in and around Lahore. The effect of drugs on DLC and haemoglobin was also determined. For this purpose 350 healthy and suspected horses were examined. Thirty positive cases were divided into 3 equal groups. Two groups were served with two different trials, and 3rd group was kept as untreated infected control. A 4th group was kept as non-infected and untreated control. All the animals were examined at regular intervals for the presence or absence of parasites post-treatment. The DLC and haemoglobin contents were recorded just before and on day 21 post-treatment. The data so obtained was analysed statistically and results were made as under.

1) Prevalence

Out of 350 horses, 37 were positive to T.evansi. The prevalence was 10.57 percent.

2) Efficacy

The Suramin (Naganol Bayer) was 70% Trypanocidal on day 0 and 100Z on day 10 and 21 post treatment; while the Quinapyrainine (Trypacide N & B) was 80% effective on day 5 and 100% on day 10 and 21 post treatment.

3) DLC

Harked Neutropenia with lymphocytosis was observed before tree tinent. The average values of Neutrophils were 42.5 ± 0.65.. 42.6 ± 0.61, 42.7 .± 0.65 and 61.4 .± 0.48 in the 4 groups respectively. The reduction in Neutrophils and increase in lymphocytes was 30.62% and 69.96%. On day 21 after treatment Neutrophil and lymphocyte count became 61.8 ± 0.41 and 55.1 .± 0.56 in group I and II respectively; while the group III and IV revealed no difference in their count. There was 35% increase in Eosinophils of group I, II and III before treatment, the average being 5.6 ± 0.26, 5.2 ± 0.24 and 5.4 ± 0.27 respectively: while the group IV possessed 4.00 ± 0.23% neutrophils. The eosjnophjlja tended to become normal with 29.63% decrease, average being 3.9 ± 0.4 and 3.7± 0.56 in group I and II respectively) on day 21 post-treatment; while this count remained nearly the same in group IV on same day.

The Basophil count remained unchanged before and - after treatment in all the 4 groups. The average values on day 0 were 1.7 ± 0.17, 1.5 ± 0.17, 1.2 ± 0.16 and 1. 1 ± 0. 16 and on day 21 1.6 ± 0. 16, 1.1 ± 0.16, 1.5 ± 0.17 and 1.6 ± 0.2 for group I, II, III and IV respectively.

4) Haemoglobin

There was 38. 78% decrease in haemoglobin content in infected animals. The average values raised up after treatment from 6.03 ± 0.17 and 6.21 ± 0.13 to 8.24 ± 015 and 7.22 ± 0.19 with Suramin (Naganol Bayer) and Trypacide N & B respectively. Suramin (Naganol Bayer) was significantly better than Trypacide N & B in that respect. There was 15.29% decrease in group III after 21 days. The haemoglobin values of group IV remained unchanged.

5) Side Effects

The 40% horses treated with Suramin (Naganol Bayer) revealed signs of hypersensitivity. The 50% of animals treated with Trypacide N & B developed oedemas. at the site of injection.

Note: Quinapyraroine (Trypacide N & B) was concluded to be the drug of choice for equine Trypanosomiasis.

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