Comparative Efficacy Of Three Newly Introduced Drugs For The Control Of Experimentally Induced Coccidiosis In Broiler Chicks
By: Aslam, M
| Dr. M. Sarwar Khan.
Contributor(s): dr. Kamran | Dr. Khalid Pervaz | Faculty of Veterinary Sciences.
Material type: 
BookPublisher: 1998Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 0561,T Dissertation note: One hundred and fifty brioler chicks reared under standars and managmental conditions, were divided into five groups A, B, C, D and E each comprising 30 birds at the ag of 21 days. From 22nd day to onward group A, B and C were given feed mixed with coccidiostats i.e. diclazuril (200mg/kg of feed), maduramicin ammonium 500mg/kg of feed) and salinomycin (1gm/kg of feed) respectively till the end of experiment while group D and E were fed with usual feed. On 28th day, the group A, B, C and D were infected with 75000, sporulated occyst/bird while gropu E was non-infected non-medicated control.
Clinical signs were observed only in group B, C and D. The total oocyst count in all groups on zero day of infection was zero. On 1st, 4th and 8th day after the appearance of clinical symptoms, the total oocyst count in group A, B, C and D were 2500, 4900, 9700 and 209600 respectively, while group E examined nil being control non-infected group. Morbidity observed in group B, C and D was 3.33% 16.66% and 83.33% respectively while in group A and E morbidity was not observed. Mortality was observed only in groups C and D that was 3.33% and 30% respectively.
The feed intake and feed conversion ratio of group A, B and C was almost equal, while of group D (infected and non-medicated) is concerned it showed better result. Postmortem examination revealed severe enteritis an hemorrhagic lesions in small intestines and caeca, while on histopathology, damage to the absorptive tissue and destructions of the intestinal villi alongwith the merozoites, schizonts and gametocytes in the mucosa and sub-mucosal region of intestine and caeca were observed.
The study showed the prophylactic efficacy of diclazuril, maduramicin ammonium and salinomycin in descending ordre respectively. Diclazuril was to be the drug of choic against coccidiosis.
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One hundred and fifty brioler chicks reared under standars and managmental conditions, were divided into five groups A, B, C, D and E each comprising 30 birds at the ag of 21 days. From 22nd day to onward group A, B and C were given feed mixed with coccidiostats i.e. diclazuril (200mg/kg of feed), maduramicin ammonium 500mg/kg of feed) and salinomycin (1gm/kg of feed) respectively till the end of experiment while group D and E were fed with usual feed. On 28th day, the group A, B, C and D were infected with 75000, sporulated occyst/bird while gropu E was non-infected non-medicated control.
Clinical signs were observed only in group B, C and D. The total oocyst count in all groups on zero day of infection was zero. On 1st, 4th and 8th day after the appearance of clinical symptoms, the total oocyst count in group A, B, C and D were 2500, 4900, 9700 and 209600 respectively, while group E examined nil being control non-infected group. Morbidity observed in group B, C and D was 3.33% 16.66% and 83.33% respectively while in group A and E morbidity was not observed. Mortality was observed only in groups C and D that was 3.33% and 30% respectively.
The feed intake and feed conversion ratio of group A, B and C was almost equal, while of group D (infected and non-medicated) is concerned it showed better result. Postmortem examination revealed severe enteritis an hemorrhagic lesions in small intestines and caeca, while on histopathology, damage to the absorptive tissue and destructions of the intestinal villi alongwith the merozoites, schizonts and gametocytes in the mucosa and sub-mucosal region of intestine and caeca were observed.
The study showed the prophylactic efficacy of diclazuril, maduramicin ammonium and salinomycin in descending ordre respectively. Diclazuril was to be the drug of choic against coccidiosis.
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