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Comparative Efficacy Of Various Drugs Used Against Equine Colic

By: Hamad Bin Rashid | Dr.Khalid Pervez.
Contributor(s): Dr.Asim Aslam | Dr.Muhammad Ashraf | Faculty of Veterinary Sciences.
Material type: materialTypeLabelBookPublisher: 1999Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 0599,T Dissertation note: Horse is a delicate animal and has a marked tendency towards gastro-intestinal disorders. Unlike other diseases of equines, colic provides the horse a lot pain, the veterinarian and the horse owner much anguish and loss. This study was designed to evaluate the efficacy of hyoscine-n-butylbromide, pentazocine lactate and detomidine hydrochloride. Eighteen horses suffering from colic brought to the Veterinary Hospital, Lahore Race Club, Lahore and the Outdoor Hospital, College of Veterinary Sciences, Lahore were used in this study, while 6 normal horses were kept as control. rI1i diseased horses were randomly divided into A, B and C groups. The physical examination of the affected animals was performed to determine the degree of dehydration, PCV and concentration of serum electrolytes i.e. Sodium, Potassium, Chloride and Bicarbonate were measured before treatment, 1 hour and 2 hour post treatment by flame photometry. In healthy animals PCV and serum electrolytes were in normal range. Increased PCV was observed in most of the affected horses (range 27-64% Mean 43.22%). One hour after the treatment the PCV ranged from 29.1-62.8% (Mean 43.82) while after 2 hours, It was 30.82-60.1% (Mean 43.77%). The lower values of PCV could be attributed to parasitic anaemia. Serum Sodium, Chloride and Bicarbonate concentrations were decreased i.e. 108-13 1 mEq/L (Mean 118.88), 70-91 mEq/L (Mean 79.26) and 23.3-31.1 mEq/L (Mean 26.67) respectively. While serum Potassium concentration was increased i.e. 3.0-5.4 mEq/L (Mean 4.25). One hour after the treatment the values of Nat, OF, HC03 and K were 108.8-132.4 (Mean 121.1), 74.1-94 (Mean 81.6), 24-31.4 (Mean 27.24), 3.3-5.2 mEq/L (Mean 4.39), respectively, while 2 hours after the treatment the values of Na, CF, HC03 and K were 109-133.1 (Mean 122.97), 74.5-99 (Mean 83.55), 24.5-31.9 (Mean 27.83) and 3.7-5.1 mEq/L (Mean 4.53) respectively. The efficacy of hyoscine-n-butylbromide was 100% within 5 hours post treatment. The efficacy of pentazocine lactate was 100% within 4 hours post treatment, while the efficacy of detomidine hydrochloride was 100% 4 hours post treatment. Among pentazocine and detomidine, the efficacy of detomidine was better as more horses recovered in the same time period as compared to pentazocine.
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Horse is a delicate animal and has a marked tendency towards gastro-intestinal disorders. Unlike other diseases of equines, colic provides the horse a lot pain, the veterinarian and the horse owner much anguish and loss. This study was designed to evaluate the efficacy of hyoscine-n-butylbromide, pentazocine lactate and detomidine hydrochloride. Eighteen horses suffering from colic brought to the Veterinary Hospital, Lahore Race Club, Lahore and the Outdoor Hospital, College of Veterinary Sciences, Lahore were used in this study, while 6 normal horses were kept as control. rI1i diseased horses were randomly divided into A, B and C groups. The physical examination of the affected animals was performed to determine the degree of dehydration, PCV and concentration of serum electrolytes i.e. Sodium, Potassium, Chloride and Bicarbonate were measured before treatment, 1 hour and 2 hour post treatment by flame photometry.
In healthy animals PCV and serum electrolytes were in normal range. Increased PCV was observed in most of the affected horses (range 27-64% Mean 43.22%). One hour after the treatment the PCV ranged from 29.1-62.8% (Mean 43.82) while after 2 hours, It was 30.82-60.1% (Mean 43.77%). The lower values of PCV could be attributed to parasitic anaemia. Serum Sodium, Chloride and Bicarbonate concentrations were decreased i.e. 108-13 1 mEq/L (Mean 118.88), 70-91 mEq/L (Mean 79.26) and 23.3-31.1 mEq/L (Mean 26.67) respectively. While serum Potassium concentration was increased i.e. 3.0-5.4 mEq/L (Mean 4.25). One hour after the treatment the values of Nat, OF, HC03 and K were 108.8-132.4 (Mean 121.1), 74.1-94 (Mean 81.6), 24-31.4 (Mean 27.24), 3.3-5.2 mEq/L (Mean 4.39), respectively, while 2 hours after the treatment the values of Na, CF, HC03 and K were 109-133.1 (Mean 122.97), 74.5-99 (Mean 83.55), 24.5-31.9 (Mean 27.83) and 3.7-5.1 mEq/L (Mean 4.53) respectively. The efficacy of hyoscine-n-butylbromide was 100% within 5 hours post treatment. The efficacy of pentazocine lactate was 100% within 4 hours post treatment, while the efficacy of detomidine hydrochloride was 100% 4 hours post treatment. Among pentazocine and detomidine, the efficacy of detomidine was better as more horses recovered in the same time period as compared to pentazocine.

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