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Effects Of Stress Folowing Vaccination (Avinew) Against Newcastle Disease In Broilers

By: Asaf Jamal Khan, Major M | Dr.Asim Aslam.
Contributor(s): Dr.Irshad | Dr.Sohail Akhtar Khan | Faculty of Veterinary Sciences.
Material type: materialTypeLabelBookPublisher: 2000Subject(s): Department of PathologyDDC classification: 0674,T Dissertation note: This experiment was designed to find out the degree of stress and immune status in response to vaccination (Avinew) against ND and also to know the effects of two therapeutic agents, i.e. multivitaminsand aspirin, on efficacy of the vaccine. One hundred and sixty day old broiler chicks were divided into four groups i.e. A, B, C and D, each group having 40 birds. Group A was kept as control, B was vaccinated but non-medicated, group C was given multivitamins alongwith vaccine for 3 post-vaccination days and group D was treated with aspirin for 3 post-vaccination days. Blood samples were collected on days 1st, 14th, 28th and 42nd for detection of antibody titer against NDV. Blood samples were collected from 10 randomly selected birds of each group after 24, 48 and 72 hours of vaccination for study of heterophil/lymphocyte ratio and estimation of serum biochemical substances (protein, glucose and cholesterol). On 42nd day of the experiment, adrenal glands of 10 randomly selected birds from each group were examined for adrenal/body weight ratio and gross/histopathological lesions. At the end of the experiment the economics of the flocks was also calculated. "AVINEW" (freezed dried live VG/GA vaccine) against Newcastle disease, activated the immune response of the chicks without any significant stress. It provided a reasonable and persistent antibody titer. Multivitamins supplementation showed immuno-potentiating effect and also positive trend in growth traits. The effect of aspirin on immune response and weight gain was variable.
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This experiment was designed to find out the degree of stress and immune status in response to vaccination (Avinew) against ND and also to know the effects of two therapeutic agents, i.e. multivitaminsand aspirin, on efficacy of the vaccine. One hundred and sixty day old broiler chicks were divided into four groups i.e. A, B, C and D, each group having 40 birds. Group A was kept as control, B was vaccinated but non-medicated, group C was given multivitamins alongwith vaccine for 3 post-vaccination days and group D was treated with aspirin for 3 post-vaccination days. Blood samples were collected on days 1st, 14th, 28th and 42nd for detection of antibody titer against NDV. Blood samples were collected from 10 randomly selected birds of each group after 24, 48 and 72 hours of vaccination for study of heterophil/lymphocyte ratio and estimation of serum biochemical substances (protein, glucose and cholesterol). On 42nd day of the experiment, adrenal glands of 10 randomly selected birds from each group were examined for adrenal/body weight ratio and gross/histopathological lesions. At the end of the experiment the economics of the flocks was also calculated. "AVINEW" (freezed dried live VG/GA vaccine) against Newcastle disease, activated the immune response of the chicks without any significant stress. It provided a reasonable and persistent antibody titer. Multivitamins supplementation showed immuno-potentiating effect and also positive trend in growth traits. The effect of aspirin on immune response and weight gain was variable.

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