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Therapeutic And Prophylactic Effects Of Antimicrobial Agents Against Omphalitis In Broiler Chicks

By: Qamar Arif | Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. M. Ovais Omer | Dr. Shakil.
Material type: materialTypeLabelBookPublisher: 2002Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 0792,T Dissertation note: The Project was designed to study therapeutic and prophylactic effect of antimicrobial agents against omphalitis in the broiler chicks. Three hundred and seventy five day-old chicks were divided into two groups for therapeutic and prophylactic trails containing 200 and 175 chicks respectively. Therapeutic trail group was sub-divided into live groups A, B, C, D and E containing forty chicks in each. Chicks of group "A" served as non-infected, non-treated control. Infection was induced in group 13, C, D and E on first day. After 24 hours post infection, five chicks from each group were randomly slaughtered to observe the postmortem lesions of omphalitis. Trizine, Mycomas and Vetymoxil C medication was done in groups C, 1) and E respectively from 2nd to 5th day after the confirmation of omphalitis. Prophylactic trail group was also sub-divided into five groups A, 13, C, D ail E containing 35 chicks each. Group "A" served as non-infected, non-treated control. Chicks of group C, I) and E were first given medication of Trizine, Mycomas and Vety-moxil C respectively as a prophylactic measure for first 3 days of life. Then infection of confirmed pathogen of E. coil was given to group B, C, D and E on the 4th day of life. Therapeutic and prophylactic effect of Trizine, Mycomas and Vetymoxil C was compared based on feed consumption, mortality, clinical findings and postmortem lesions. The results indicated that the treatment and prophylactic use of Mycomas, Trizine and Vety-moxil C were effective against omphalitis to reduce the early chick mortality. During therapeutic trials Mycomas cure rate was better than the Vety-moxil C and Trizine. In prophylactic trails Mycomas provided better protection followed by Vety-moxil C and trizine. Therefore Mycomas may be used to reduce the early chick mortality caused by omphalitis.
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The Project was designed to study therapeutic and prophylactic effect of antimicrobial agents against omphalitis in the broiler chicks. Three hundred and seventy five day-old chicks were divided into two groups for therapeutic and prophylactic trails containing 200 and 175 chicks respectively. Therapeutic trail group was sub-divided into live groups A, B, C, D and E containing forty chicks in each. Chicks of group "A" served as non-infected, non-treated control. Infection was induced in group 13, C, D and E on first day. After 24 hours post infection, five chicks from each group were randomly slaughtered to observe the postmortem lesions of omphalitis. Trizine, Mycomas and Vetymoxil C medication was done in groups C, 1) and E respectively from 2nd to 5th day after the confirmation of omphalitis. Prophylactic trail group was also sub-divided into five groups A, 13, C, D ail E containing 35 chicks each. Group "A" served as non-infected, non-treated control. Chicks of group C, I) and E were first given medication of Trizine, Mycomas and Vety-moxil C respectively as a prophylactic measure for first 3 days of life. Then infection of confirmed pathogen of E. coil was given to group B, C, D and E on the 4th day of life. Therapeutic and prophylactic effect of Trizine, Mycomas and Vetymoxil C was compared based on feed consumption, mortality, clinical findings and postmortem lesions.

The results indicated that the treatment and prophylactic use of Mycomas, Trizine and Vety-moxil C were effective against omphalitis to reduce the early chick mortality. During therapeutic trials Mycomas cure rate was better than the Vety-moxil C and Trizine. In prophylactic trails Mycomas provided better protection followed by Vety-moxil C and trizine.

Therefore Mycomas may be used to reduce the early chick mortality caused by omphalitis.

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