The experiment was designed to study the effect of coccidiosis vaccine in comparasion with chemo-prophylactic and therapeutic measures against coccidiosis and their effect on weight gain, mortality and blood parameters in broiler breeder birds. For this purpose one hundred and twenty day-old broiler breeder chicks were obtained from local market and reared in the Experimental room of the Medicine Section, College of Veterinary Sciences (CVS), Lahore under standard managemental conditions upto 49 days of age. The birds were fed on commercial coccidiostat free feed purchased from the market The following materials (vaccines, medicine, caeca) were used

1. Local vaccine (Eimeria vaccine) was obtained from Parasitology Laboratory, CVS., Lahore.

2. Imported vaccine (Immucox; Vetec Laboratories, Canada) was purchased from the market.

3. Amprolium 60% was purchased from Grace Pharma, Lahore.

4. The infected caeca of broiler chicks was obtained from different farms and diagnostic laboratories.

One hundred and twenty day-old broiler breeder birds were divided into eight groups comprising of 15 birds in each group. Different groups were arranged according to the following pattern:

Group A. was non-infected control group, group-B was infected control group. Infection was given on day 22, group-C was vaccinated infected group. Local vaccine was given on 3rd and 10th day of age followed by the dose of 30,000 sporulated oocyst at 22nd day of age. Group-D was vaccinated with local vaccine (non infected). Group-E was vaccinated infected group. Imported vaccine was given at 7th day followed by infection at 22nd day. Group-F was vaccinated with imported coccidial vaccine, non-infected group. Group-G was infected and treated group. Infection was given on day 22 of age and the birds will be treated with Amprolium 60% at the dose of lg/2 litre of drinking water for 5 consecutive days. Group-H was non-Infected, treated with Amprolium 60% at the dose of lg/2 litre of drinking water for 5 consecutive days.

The weight of birds was weekly recorded starting from day one upto the end (42nd day) of the experiment. Faecal examination for the counting of oocyst per gram of faeces were recorded after every 4th day of the administration of infection.

It was observed that the performance of the birds of group D (noninfected, vaccinated with local vaccine) was the best as compared to all other experimental groups. However, group E (infected, vaccinated with Imported coccidial vaccine) was also given good performance.