Studies On Nonsteroidal Anti-Inflammatory Drugs (Nsaids) Toxicity In Broilers
By: Asif Farooq Awan
| Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. Khushi | Dr. Muhammad Ovais Omer | Faculty of Biosciences.
Material type: 
BookPublisher: 2005Subject(s): Department of PhysiologyDDC classification: 0892,T Dissertation note: This project was designed for the evaluation of different effects of toxic dosage levels of NSAIDs (piroxicam, ketoprofen, phenyl-butazone and dipyron) in broiler chickens. For this project two hundred and twenty five healthy broiler chickens were purchased from the market and were reared upto 28 days. Then one hundred and twenty five were divided into five groups A, B, C, D and E having twenty five birds in each group. On day 29th four groups A, B, C and D were medicated with piroxicam, ketoprofen, phenyl-butazone and dipyron twice a day at dose rate of 1, 5, 50 and 50 mg/kg body weight respectively intra-muscularly for four days. Birds from group E were kept as control. Feed and water were provided ad libitum. A physical examination was performed daily. Signs of toxicity and mortality rate in each group was recorded. Blood samples from wing vein (3 ml) was drawn on day 29 before medication and on days 33, 37, 41 after medication from same birds for determination of serum values of Aspartate Transaminase (AST), Alanine Transaminase (ALT), Uric Acid, Alkaline phosphatase (ALP), and Creatinine. Postmortem examinationwas performecd after all samples taken.
In second experiment other 100 birds were divided into five groups K, L, M, N and O comprising of 20 birds in each group. Each bird of group K was injected I/M piroxicam 2 mg/kg twice a day. Each bird of group L was injected I/M ketoprofen 10 mg/kg twice a day. Each bird of group M was injected I/M phenyl buazone 100 mg/kg twice a day. Each bird of group N was injected I/M metamizole 100 mg/kg body weight for twice a day upto four days and group 0 was kept as control group. Postmortem examination was performed after medication. Based on the necropsy findings and biochemical analysis it was found that piroxicam was safest drug (NSAIDs) in the avian species. Keeping in view the environmental problem of decline in population and its possible link with Diclodenic sodium,(vultures arises) it is recommended that piroxicam which has good pharmacological effects in human medicines may be used instead of diclofenac sodium in veterinary practice.
| Item type | Current location | Collection | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|
Thesis
|
UVAS Library Thesis Section | Veterinary Science | 0892,T (Browse shelf) | Available | 0892,T |
Browsing UVAS Library Shelves , Shelving location: Thesis Section , Collection code: Veterinary Science Close shelf browser
This project was designed for the evaluation of different effects of toxic dosage levels of NSAIDs (piroxicam, ketoprofen, phenyl-butazone and dipyron) in broiler chickens. For this project two hundred and twenty five healthy broiler chickens were purchased from the market and were reared upto 28 days. Then one hundred and twenty five were divided into five groups A, B, C, D and E having twenty five birds in each group. On day 29th four groups A, B, C and D were medicated with piroxicam, ketoprofen, phenyl-butazone and dipyron twice a day at dose rate of 1, 5, 50 and 50 mg/kg body weight respectively intra-muscularly for four days. Birds from group E were kept as control. Feed and water were provided ad libitum. A physical examination was performed daily. Signs of toxicity and mortality rate in each group was recorded. Blood samples from wing vein (3 ml) was drawn on day 29 before medication and on days 33, 37, 41 after medication from same birds for determination of serum values of Aspartate Transaminase (AST), Alanine Transaminase (ALT), Uric Acid, Alkaline phosphatase (ALP), and Creatinine. Postmortem examinationwas performecd after all samples taken.
In second experiment other 100 birds were divided into five groups K, L, M, N and O comprising of 20 birds in each group. Each bird of group K was injected I/M piroxicam 2 mg/kg twice a day. Each bird of group L was injected I/M ketoprofen 10 mg/kg twice a day. Each bird of group M was injected I/M phenyl buazone 100 mg/kg twice a day. Each bird of group N was injected I/M metamizole 100 mg/kg body weight for twice a day upto four days and group 0 was kept as control group. Postmortem examination was performed after medication. Based on the necropsy findings and biochemical analysis it was found that piroxicam was safest drug (NSAIDs) in the avian species. Keeping in view the environmental problem of decline in population and its possible link with Diclodenic sodium,(vultures arises) it is recommended that piroxicam which has good pharmacological effects in human medicines may be used instead of diclofenac sodium in veterinary practice.
There are no comments for this item.