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Bioavailability Of Amoxicilin Trihydrate In Broiler Chickens Administered Through Drinking Water

By: Amir Bakhsh | Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. Muhammad Ovais Omer | Prof. Dr | Faculty of Biosciences.
Material type: materialTypeLabelBookPublisher: 2004Subject(s): Department of PhysiologyDDC classification: 0894,T Dissertation note: Bioavailability of two oral commercial formulations of amoxicillin trihydrate i.e. oracin-50 (Mediexcel, Pharmaceuticals (Pvt.) Limited Pakistan) and Bioxil-20 (Bioceutica, µµchickens. The birds were divided into two groups A and B and than six replicates of each group were made. The birds were reared upto 30 days. Group A was medicated by Oracin-50 and group B was medicated by Bioxil-20. The medication was continued for three consecutive days and blood samples were collected before and after medication as per schedule. The plasma level of amoxicillin were determined by microbiological assays. The concentrations versus time data were plotted on logrithmic paper and various bio-availability parameters were determined. Peak concentrations of both oral preparations appeared with in two hours. However Oracin-50 peak concentration revealed 5.26±1.605µg/ml which was not significantly higher than 4.71±0.142ig/ml as depicted by Bioxil-20. Mean ±SEM of the area under curve (AUC) for Oracin-50 was 296.783±6.331µg. hr/ml and 259.26±4.866 µg.hr/ml for Bioxil-20 statistical analyses revealed no significant different minimum concentration of Oracin-50 revealed 2.550±O.0763µg/ml while 2.450±O.07637µg/ml as depicted by the bioxil-20. Both the preparations took the same time (2 hour) to attain the peak level of the plasma concentration. The present study also revealed that amoxicillin is not much stable in water. Oracin-50 decreased 34% and Bioxil-20 decreased 35% in 72 hours There was no significant difference (P<O.05) in the stability of both groups. The comparative study of the two Pharmaceutical preparations Oracin-50 (Mediexcel Pharmaceutical Pakistan) and Bioxil-20 (Bioceutica Pharmaceutical Pakistan) revealed that there was no significant difference (P<O.05) between the means of two groups. The statistical evaluation revealed bio-equaleancy between two drugs. Amoxicillin is broad spectrum antibiotic, its bioavailability is better than other antibiotic. Its MIC is also very low (O.25igIml) but its half 1fe is short. So its repeated doses should be given. As it is somewhat unstable, in case of drinking water. The medicated water should be changed get the maximum efficacy.
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Bioavailability of two oral commercial formulations of amoxicillin trihydrate i.e. oracin-50 (Mediexcel, Pharmaceuticals (Pvt.) Limited Pakistan) and Bioxil-20 (Bioceutica, µµchickens. The birds were divided into two groups A and B and than six replicates of each group were made. The birds were reared upto 30 days. Group A was medicated by Oracin-50 and group B was medicated by Bioxil-20. The medication was continued for three consecutive days and blood samples were collected before and after medication as per schedule. The plasma level of amoxicillin were determined by microbiological assays. The concentrations versus time data were plotted on logrithmic paper and various bio-availability parameters were determined.

Peak concentrations of both oral preparations appeared with in two hours. However Oracin-50 peak concentration revealed 5.26±1.605µg/ml which was not significantly higher than 4.71±0.142ig/ml as depicted by Bioxil-20.

Mean ±SEM of the area under curve (AUC) for Oracin-50 was 296.783±6.331µg. hr/ml and 259.26±4.866 µg.hr/ml for Bioxil-20 statistical analyses revealed no significant different minimum concentration of Oracin-50 revealed 2.550±O.0763µg/ml while 2.450±O.07637µg/ml as depicted by the bioxil-20.

Both the preparations took the same time (2 hour) to attain the peak level of the plasma concentration. The present study also revealed that amoxicillin is not much stable in water. Oracin-50 decreased 34% and Bioxil-20 decreased 35% in 72 hours There was no significant difference (P
Amoxicillin is broad spectrum antibiotic, its bioavailability is better than other antibiotic. Its MIC is also very low (O.25igIml) but its half 1fe is short. So its repeated doses should be given. As it is somewhat unstable, in case of drinking water. The medicated water should be changed get the maximum efficacy.

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