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Comparative Efficacy Of Various Antiviral Agents Avian Influenza Virus(Type H7)

By: Tahir Mahmood Shaukat | Prof.Dr.Muhammad Ashraf.
Contributor(s): ghjgh | Prof.Dr.Khushi.
Material type: materialTypeLabelBookPublisher: 2007Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 0900,T Dissertation note: In this project 3 different concentrations of each of amantadine HC1, extracts of fresh leaves of opuntia herb, papaya and dried powdered leaves of green tea in distilled water were evaluated for their antiviral activity, by injecting into 10 days old live embryonated broiler chicken eggs through chorioallantoic sac route. For each drug embryonated eggs were treated only with it's 3 different concentrations to evaluate toxicity, whereas to check antiviral efficacy, embryonated eggs were treated with suspensions of three different concentrations of drug with 4HA titre of AIV (type H7). In case of amantadine HC1 out of 50ug/ml, 500ug/ml and l000ug/ml concentrations only 500ug/ml was found to be an ideal concentration, as in addition to stop virus growth it also did not kill the embryos. In case of Opuntia dellinii all the 3 concentrations used were not toxic for embryos, but antiviral oeffect was observed only by 4gm and 8gm/100ml concentrations. Green tea extract was found to be effective against AIV only at 8gm/100ml concentration with no damage to chick embryos. Papaya leaves extract as a whole failed to check virus replication at all the three concentrations used in this experiment i.e. 2gm, 4gm and 8gm/100ml. All these dose levels were not lethal for chick embryos.
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In this project 3 different concentrations of each of amantadine HC1, extracts of fresh leaves of opuntia herb, papaya and dried powdered leaves of green tea in distilled water were evaluated for their antiviral activity, by injecting into 10 days old live embryonated broiler chicken eggs through chorioallantoic sac route. For each drug embryonated eggs were treated only with it's 3 different concentrations to evaluate toxicity, whereas to check antiviral efficacy, embryonated eggs were treated with suspensions of three different concentrations of drug with 4HA titre of AIV (type H7).

In case of amantadine HC1 out of 50ug/ml, 500ug/ml and l000ug/ml concentrations only 500ug/ml was found to be an ideal concentration, as in addition to stop virus growth it also did not kill the embryos. In case of Opuntia dellinii all the 3 concentrations used were not toxic for embryos, but antiviral oeffect was observed only by 4gm and 8gm/100ml concentrations. Green tea extract was found to be effective against AIV only at 8gm/100ml concentration with no damage to chick embryos. Papaya leaves extract as a whole failed to check virus replication at all the three concentrations used in this experiment i.e. 2gm, 4gm and 8gm/100ml. All these dose levels were not lethal for chick embryos.

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