Bioavailability Of Tylosin Tartrate After Flock Medication Via Drinking Water In Broilers
By: Shahid Bashir
| Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. Muhammad | Dr. Muhammad Ovais Omer.
Material type: 
BookPublisher: 2004Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 0944,T Dissertation note: Microbiological assay was used to determine the biological availability of tylosin tartrate in broiler chickens with bascillus subtillus as a test organism. Two groups of birds were made (A & B). Group A was medicated with Tyloexcel and group B with Tyleco soluble. Then blood samples were collected serially. Plasma concentration was found by using microbiological assay and the obtained data was compared with published pharmacokinetic data. Stability of two products (using the same technique) showed both products are equally stable in water and no significant difference is between these two products. In the present research Maximum time (tmax) 2 hours for tylosin obtained after oral administration indicates that using this antibiotic with driking water in broiler chickens is the method of choice. However, relatively, low value of Maxmimum plasma concentration (Cpmax) 1.28±0.030 g/ml (Tyloexcel) and 1.2±0.025 g/ml (Tyleco soluble) after oral administration of tylosin shows that dosing of this antibiotic in chickens should be higher than in other food producing animals.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 0944,T (Browse shelf) | Available | 0944,T |
Microbiological assay was used to determine the biological availability of tylosin tartrate in broiler chickens with bascillus subtillus as a test organism. Two groups of birds were made (A & B). Group A was medicated with Tyloexcel and group B with Tyleco soluble. Then blood samples were collected serially. Plasma concentration was found by using microbiological assay and the obtained data was compared with published pharmacokinetic data. Stability of two products (using the same technique) showed both products are equally stable in water and no significant difference is between these two products. In the present research Maximum time (tmax) 2 hours for tylosin obtained after oral administration indicates that using this antibiotic with driking water in broiler chickens is the method of choice. However, relatively, low value of Maxmimum plasma concentration (Cpmax) 1.28±0.030 g/ml (Tyloexcel) and 1.2±0.025 g/ml (Tyleco soluble) after oral administration of tylosin shows that dosing of this antibiotic in chickens should be higher than in other food producing animals.
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