This study was designed to compare and evaluate therapeutic anticoccidial efficacy of herbal drug (steroidal sapogenin), suipha drug (suiphachiorpyrazine) and Amproliurn.

Total of 150, a day-old broiler chicks were reared for six weeks in good husbandry and hygienic conditions. Coccidiosis was induced in broiler chickens in cages (battery system). The oocysts were collected from already infected poultry guts and were processed and sporulated in potassium dichromate solution according to the standard method of floatation and then the sporulated oocysts were counted by McMaster technique and were inoculated into birds as per required dose rate to induce coccidiosis in birds of group A, B, C and D.

Coccidiosis was diagnosed on standard postmortem procedure and oocyst counting of the fecal droppings of the infected birds. Group A, B and C was medicated by sulphachlorpyarazine (Esb3), steroidal sapogenin (cocciguard) and amprolium (cocoban) respectively. Group D were infected but left un-medicated positive control and group E were left non infected and non medicated negative control.

The therapeutic efficacy of the above mentioned drugs were evaluated by oocyst counting in droppings of all the infected treated groups and by intestinal lesion scoring, bloody diarrhea. Morbidity and mortality were recorded in all infected groups before and after treatment. Oocyst counting was done in all groups after induction of coccidial infection and at the end of the treatment in all medicated groups.

Oocyst counting and intestinal lesion scoring were helpful in evaluation of the therapeutic efficacy of the cocciguard (steroidal sapogenin) in comparison with the chemical anticoccidial drugs.

The following recorded parameters, oocyst counting, morbidity, mortality, bloody diarrhea, intestinal lesion scoring were subjected to statistical analysis using one way analysis of variance, to detect the therapeutic efficacy difference between treatments and the results obtained are as follows.

Oocyst per gram was 1.49*0.78, 20.36±1.89, 2.66±1.47 and 47.7±4.3 for suiphachlorpyrazine, steroidal sapogenin, amprolium and positive control respectively.
Morbidity recorded was 1.5±0.87, 2.75±0.47, 2.25±0.25, and 2.25±0.25 for sulphachlorpyrazine, steroidal sapogenin amprolium and positive control respectively.
Mortality recorded was 0.40±0.24, 2.40±0.24, 1.80±0.2, and 2.40±0.24 for suiphachiorpyrazine, steroidal sapogenin, amprolium and positive control.
Intestinal lesion scoring recorded was 1.5±0.35, 2.5±0.20, and 1.62±0.12 for sulphachlorpyrazine, steroidal sapogenin, and amprolium respectively.
Survival rate recorded was 56%, 20%, 33.30%, 0%, and 93.3% in suiphachlorpyrazine, steroidal sapogenin, amprolium, positive control, and negative control group respectively.
Percent reduction in oocyst per gram was recorded 97.48%, 18.58%, and 97.19% in suiphachiorpyrazine, steroidal sapogenin and amprolium respectively.