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Study Of Hypoglycemic & Antihyperlipidemic Effect Of Ethanolic Extract Of Gymnema Sylvestre

By: Shagufta Perveen | Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr.Muhammed Ovais Omer | Muhammed.
Material type: materialTypeLabelBookPublisher: 2008Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 1041,T Dissertation note: Gymnema sylvestre (Gurmar booti) is a herb native to the tropical forests of southern and central India. This project was designed to study the hypoglycemic and antihyperlipidemic effect of ethanolic extract of Gymnema sylvestre in alloxan induced diabetes in rabbits. For this purpose thirty rabbits were divided into six groups i.e. A, B, C, D, E and F having 5 rabbits in each group. Group A was taken as control and no treatment was given to control group. Group B was taken as control group for hyperlipidemia and it was treated with cholesterol powder at a rate of 600mg/Kg body weight orally daily for 15 days. Group C was treated with cholesterol powder at a rate of 600mg/Kg body weight orally daily to produce hyperlipidemia after 5 days this Group was treated with ethanolic extract of Gymnema sylvestreat at a rate of 400mg/Kg body weight orally daily for 15 days. In other groups diabetes were induced by treating them with alloxan at a rate of 150mg/Kg body weight intravenously into the marginal ear vein. The rabbits were monitored for a week for the development of diabetes by measuring glucose level, then they were treated. The Group D was taken as diabetic control group. Group E was treated with glibenclamide at a rate of 600p.g/kg body weight orally for 15 days. Group F was given ethanolic extract of Gymnema sylvestre at a rate of 400mg/kg body weight daily for 15 days. After the administration of ethanolic extract of Gymnema sylvestre, the animal was held in the wooden holder and 2 ml of the blood was obtained from the juglar vein with the help of syringe and serum glucose level and different biochemical parameters of lipid profile were estimated with the help of a UV-spectrophotometer. The samples were collected at 0, 5, 10 and 15 days. On the basis of results it was concluded that ethanolic extract of Gymnema sylvestre has a significant hypoglycemic effect in diabetic rabbits and their effect was comparable to that of gilbenclamide. Therefore, this medicinal plant is considered to be effective and alternative treatment for diabetes. Ethanolic extract of Gymnema sylvestre also has a significant antihyperlipidemic effect.
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Gymnema sylvestre (Gurmar booti) is a herb native to the tropical forests of southern and central India. This project was designed to study the hypoglycemic and antihyperlipidemic effect of ethanolic extract of Gymnema sylvestre in alloxan induced diabetes in rabbits. For this purpose thirty rabbits were divided into six groups i.e. A, B, C, D, E and F having 5 rabbits in each group. Group A was taken as control and no treatment was given to control group. Group B was taken as control group for hyperlipidemia and it was treated with cholesterol powder at a rate of 600mg/Kg body weight orally daily for 15 days. Group C was treated with cholesterol powder at a rate of 600mg/Kg body weight orally daily to produce hyperlipidemia after 5 days this Group was treated with ethanolic extract of Gymnema sylvestreat at a rate of 400mg/Kg body weight orally daily for 15 days. In other groups diabetes were induced by treating them with alloxan at a rate of 150mg/Kg body weight intravenously into the marginal ear vein. The rabbits were monitored for a week for the development of diabetes by measuring glucose level, then they were treated. The Group D was taken as diabetic control group. Group E was treated with glibenclamide at a rate of 600p.g/kg body weight orally for 15 days. Group F was given ethanolic extract of Gymnema sylvestre at a rate of 400mg/kg body weight daily for 15 days. After the administration of ethanolic extract of Gymnema sylvestre, the animal was held in the wooden holder and 2 ml of the blood was obtained from the juglar vein with the help of syringe and serum glucose level and different biochemical parameters of lipid profile were estimated with the help of a UV-spectrophotometer. The samples were collected at 0, 5, 10 and 15 days. On the basis of results it was concluded that ethanolic extract of Gymnema sylvestre has a significant hypoglycemic effect in diabetic rabbits and their effect was comparable to that of gilbenclamide. Therefore, this medicinal plant is considered to be effective and alternative treatment for diabetes. Ethanolic extract of Gymnema sylvestre also has a significant antihyperlipidemic effect.

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