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Comparative Efficicy Of Peste Des Petits Ruminant (Ppr) Vaccine S Available In Pakistan In Sheep And Goats

By: Muhammad Intizar | Prof.Dr.Manur-Din-Ahmad.
Contributor(s): Dr.Aftab Ahmad Anjum | Prof.Dr.Azhar | Faculty of Veterinary Sciences.
Material type: materialTypeLabelBookPublisher: 2008Subject(s): Department of MicrobiologyDDC classification: 1051,T Dissertation note: The present study was designed to evaluate the physical factors affecting the PPR 'vaccine and also to compare the efficacy of the locally available PPR vaccines in Pakistan in sheep and goats. The current study was conducted on 120 different small ruminants ((60 sheep and goats). The humoral immune response was monitored by measuring the antibodies titre through Hl and AGID test. HI and AGID test are reliable and effective methods of diagnosing viral diseases and to evaluate the humoral immune response. It was concluded that the vaccine should he stored either at -20°C or at 4 C.The vaccine stored at 27 C had a drop in HA titre and no HA activity was found at 40 C To evaluate the HA activity of PPR virus it is better to use chicken or human group'O' R.B.Cs in a concentration of 1%. The diluent should have the pH 6.8- 7.0. By evaluating the vaccine efficacy in sheep it was found that after 14th day of vaccination there was a gradual increase in the antibodies titer till the 56th day of vaccination. The locally manufactured vaccine was having a geometric mean titre (GMT)207.9 while the (GMT) of Pestivec was 73.3. 63d day post vaccination. In goats the locally manufactured vaccine was having a geometric mean titer (GMT) 147. while the (GMT) of Pestivec was 48.5.63rd day post vaccination. No antibodies production was there in any control group. It was concluded form the study that locally produced vaccine is equally good and could be used confidently. It will save also helpful in saving the foreign reserves oh the country.
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The present study was designed to evaluate the physical factors affecting the PPR 'vaccine and also to compare the efficacy of the locally available PPR vaccines in Pakistan in sheep and goats.

The current study was conducted on 120 different small ruminants ((60 sheep and goats). The humoral immune response was monitored by measuring the antibodies titre through Hl and AGID test. HI and AGID test are reliable and effective methods of diagnosing viral diseases and to evaluate the humoral immune response.

It was concluded that the vaccine should he stored either at -20°C or at 4 C.The vaccine stored at 27 C had a drop in HA titre and no HA activity was found at 40 C

To evaluate the HA activity of PPR virus it is better to use chicken or human group'O' R.B.Cs in a concentration of 1%. The diluent should have the pH 6.8- 7.0.

By evaluating the vaccine efficacy in sheep it was found that after 14th day of vaccination there was a gradual increase in the antibodies titer till the 56th day of vaccination. The locally manufactured vaccine was having a geometric mean titre (GMT)207.9 while the (GMT) of Pestivec was 73.3. 63d day post vaccination. In goats the locally manufactured vaccine was having a geometric mean titer (GMT) 147. while the (GMT) of Pestivec was 48.5.63rd day post vaccination. No antibodies production was there in any control group.

It was concluded form the study that locally produced vaccine is equally good and could be used confidently. It will save also helpful in saving the foreign reserves oh the country.

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