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Disposition Kinetics Of Oxytetracycline In Sheep

By: Rana Fatima | Dr. Muhammad Nawaz.
Contributor(s): Mr. Riaz ul Haq Siddique.
Material type: materialTypeLabelBookPublisher: 1985Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 1144,T Dissertation note: The pharmacokinetic s of ooxytetracycline was investigated in eight normal adult female sheep after intravenous administration. The blood samples collected at various time intervals were assayed for unchanged oxytetracycline. The plasma concerntrations of oxytetracycline at different time intervals from 5 minutes to 24 hours ater injection were plotted on semilograthmic graph paper versus time. The results are expressed after performing two compartment model kinetic analysis. After single intravenous administration of ox tetracycline in sheep, the distribution half life and biological half life shoed average +- values of 21.52 + 5.72 and 413.75+ 25.08 minutes and ranged between 16 to 29 manures and 365 to 442 minutes, respectively. The apparent volumes of distribution of oxytetracycline in sheep calculated by area method was 1.049+ 0.0009 1/kg and ranged between 0.99 to 1.25 1/kg-1. The average + values of volume of central compartment was 0.659+ 0.005 1/kg. The rate constant for oxyteyracyline transfer across compartment 1 to 2 (k12)and 2 to 1 (k21) were an average + SEM 0.723+0.02, 1.281 + 0.03 respectively. Total body clearance of oxytetracyline through intravenous route calculated on per kg basis ranged between 91.56 to 122.88 ml. min h-1 oxytetracylcine was bound to plasma protein on an average 49.3+ .002 percent and ranged between 46 to 51 percent. The renal clearance of total and free oxytetracycline as 5.42 + 2.09 and 10.57 + 3.81 ml/min 10 kg, respectively. The results showed that the renal clearance of oxyytetracylcine involved molecular filtration and back diffusion which is independent of pH, diuresis and presence of total and free oxtetracylcine. The average + SD urinary excretion of oxytetracycline as about 18.01 + 4.03 percent of the does at 24 hourse.
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Veterinary Science 1144,T (Browse shelf) Available 1144,T
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The pharmacokinetic s of ooxytetracycline was investigated in eight normal adult female sheep after intravenous administration. The blood samples collected at various time intervals were assayed for unchanged oxytetracycline. The plasma concerntrations of oxytetracycline at different time intervals from 5 minutes to 24 hours ater injection were plotted on semilograthmic graph paper versus time. The results are expressed after performing two compartment model kinetic analysis. After single intravenous administration of ox tetracycline in sheep, the distribution half life and biological half life shoed average +- values of 21.52 + 5.72 and 413.75+ 25.08 minutes and ranged between 16 to 29 manures and 365 to 442 minutes, respectively. The apparent volumes of distribution of oxytetracycline in sheep calculated by area method was 1.049+ 0.0009 1/kg and ranged between 0.99 to 1.25 1/kg-1. The average + values of volume of central compartment was 0.659+ 0.005 1/kg. The rate constant for oxyteyracyline transfer across compartment 1 to 2 (k12)and 2 to 1 (k21) were an average + SEM 0.723+0.02, 1.281 + 0.03 respectively. Total body clearance of oxytetracyline through intravenous route calculated on per kg basis ranged between 91.56 to 122.88 ml. min h-1 oxytetracylcine was bound to plasma protein on an average 49.3+ .002 percent and ranged between 46 to 51 percent. The renal clearance of total and free oxytetracycline as 5.42 + 2.09 and 10.57 + 3.81 ml/min 10 kg, respectively. The results showed that the renal clearance of oxyytetracylcine involved molecular filtration and back diffusion which is independent of pH, diuresis and presence of total and free oxtetracylcine. The average + SD urinary excretion of oxytetracycline as about 18.01 + 4.03 percent of the does at 24 hourse.

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