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Effect Of Dietary Supplementation Of Mannanoligosaccharide On Reglamation Of Gastrointestinal Physiology In Dogs

By: Khalid Abdul Majeed | Dr. Habib ur Rehman.
Contributor(s): Dr. Muhammad Shahbaz Yousaf | Dr. Nisar | Faculty of Biosciences.
Material type: materialTypeLabelBookPublisher: 2010Subject(s): Department of PhysiologyDDC classification: 1154,T Dissertation note: The study was conducted to evaluate the effect of mannan-oligosaccharide in small bowel resection. Intestinal resection is conducted in various pathological conditions, which is necessary in alleviation of the anomaly but produces ill effects related to the physiological functioning of the resected part. Various post-operative treatments have been suggested in this regard. Prebiotics can serve as an important dietary and clinical nutritive substance with potential to stabilize aftermath. Dogs with jejunal resection were used as an experimental animal and were divided into three groups in this study. Groups were Control (con), MOS-lower dose (MOS-LD) fed 2g MOS and MOS-higher dose (MOS-HD) fed 4g MOS in addition to 400g standard diet daily. Dogs were assessed for glucose, cholesterol, white blood cell counts on day 0, 1 5, 30, 45 of MOS supplementation. Ammonia, microbiological analysis for E.coli, total aerobes and ('lostridium per/ringens were done on fecal samples collected between day 24 and 28 of MOS supplementation. Fecal scoring system was used to study alleviation of diarrhea in two periods with each of 5 days. Period 1 was from day 18 to day 22 and period 2 was from day 41 to day 45 of MOS supplementation. Repeated measures and one way ANOVA was used for analysis of data. Positive effects of MOS were evident on relieving diarrhea and increasing blood lymphocytes. Total aerobes and clostridium count decreased significantly. This study paved way for further studies in the assessment of potency of MOS and other Prebiotics in gastrointestinal surgeries and their inclusion in management of short bowel and the therapeutic arsenal.
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Thesis Thesis UVAS Library
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Veterinary Science 1154,T (Browse shelf) Available 1154,T
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The study was conducted to evaluate the effect of mannan-oligosaccharide in small bowel resection. Intestinal resection is conducted in various pathological conditions, which is necessary in alleviation of the anomaly but produces ill effects related to the physiological functioning of the resected part. Various post-operative treatments have been suggested in this regard. Prebiotics can serve as an important dietary and clinical nutritive substance with potential to stabilize aftermath. Dogs with jejunal resection were used as an experimental animal and were divided into three groups in this study. Groups were Control (con), MOS-lower dose (MOS-LD) fed 2g MOS and MOS-higher dose (MOS-HD) fed 4g MOS in addition to 400g standard diet daily. Dogs were assessed for glucose, cholesterol, white blood cell counts on day 0, 1 5, 30, 45 of MOS supplementation. Ammonia, microbiological analysis for E.coli, total aerobes and ('lostridium per/ringens were done on fecal samples collected between day 24 and 28 of MOS supplementation. Fecal scoring system was used to study alleviation of diarrhea in two periods with each of 5 days. Period 1 was from day 18 to day 22 and period 2 was from day 41 to day 45 of MOS supplementation. Repeated measures and one way ANOVA was used for analysis of data. Positive effects of MOS were evident on relieving diarrhea and increasing blood lymphocytes. Total aerobes and clostridium count decreased significantly. This study paved way for further studies in the assessment of potency of MOS and other Prebiotics in gastrointestinal surgeries and their inclusion in management of short bowel and the therapeutic arsenal.

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