Genetic Study Of Ushic/Dfnb18 By Linkage Analysis
By: Muneer Ahmad
| Mr. Tanveer Hussain.
Contributor(s): Prof. Dr. Masroor Elahi Babar.
Material type: 
BookPublisher: 2010Subject(s): Institute of Biochemistry & BiotechnologyDDC classification: 1223,T Dissertation note: Deafness refers to conditions in which individuals are fully or partially unable to detect or perceive at least some frequencies of sound which can typically be heard by members of their species. In human beings, the term hearing impairment is usually reserved for people who have relative insensitivity to sound in the speech frequencies.
In the present study, six families were identified which were collected from FATA, Lahore and Sheikhupura and were consist of at least two deaf people. Pedigrees of the affected families were drawn using Cyrillic software. Blood samples were collected from these families. DNA was extracted through Inorganic protocol. The creening of the affected families was done for known deafness locus, USH1C/ DFNBI8. Then the PAGE (Polyacrylamide Gel Eletrophoresis) was done and haplotypes were constructed to determine whether a family was linked to deafness locus or not. Out of six families, no family was linked to USHIC/ DFNB18 locus.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 1223,T (Browse shelf) | Available | 1223,T |
Deafness refers to conditions in which individuals are fully or partially unable to detect or perceive at least some frequencies of sound which can typically be heard by members of their species. In human beings, the term hearing impairment is usually reserved for people who have relative insensitivity to sound in the speech frequencies.
In the present study, six families were identified which were collected from FATA, Lahore and Sheikhupura and were consist of at least two deaf people. Pedigrees of the affected families were drawn using Cyrillic software. Blood samples were collected from these families. DNA was extracted through Inorganic protocol. The creening of the affected families was done for known deafness locus, USH1C/ DFNBI8. Then the PAGE (Polyacrylamide Gel Eletrophoresis) was done and haplotypes were constructed to determine whether a family was linked to deafness locus or not. Out of six families, no family was linked to USHIC/ DFNB18 locus.
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