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Diagnosis And Treatment Of Strongylosis Using Neem Leaves And Ivermectin In Donkeys

By: Muhammad waqas | Dr. Muhammad sarwar khan.
Contributor(s): Dr. aneela zameer durrani | Dr. Muhammad.
Material type: materialTypeLabelBookPublisher: 2011Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 1302,T Dissertation note: Donkeys act as draught animals and are used for a variety of purposes. Donkeys are still the "beasts of burden". Helminthes parasites, particularly strongyle nematodes, are the common inhabitants of the gastro-intestinal tracts of equines. Strongylosis is one of the most important parasitic diseases of equines. Diarrhea, anorexia, weight loss and moderate anaemia are the clinical signs in infected animal resulting in heavy mortality. The present project was therefore designed to investigate the infection rate of nematodes in donkeys, to calculate the efficacy of Ivermectin and Neem against strongylosis and to study the effect of strongylosis on various blood parameters (DLC and Hb). Three hundred donkeys (n=300) were examined coprologically for the presence of nematodes. 167 donkeys were found infected with various parasites with the overall infection rate being 55.66%. Out of 167, 85 donkeys were infected with strongylus, 29 with trichostrongylus, 19 with trichonema, 19 with gastrodiscuss and 15 with mixed infection. So the infection rate for strongylus, trichostrongylus, trichonema, gastrodiscuss and mixed infection was 28.33%, 9.66%, 6.33%, 6.33% and 5% respectively. For drug trails thirty donkeys naturally infected with strongylosis were selected. These animals were divided into three groups A, B and C, comprising of 10 animals each. Another group D comprising of 10 healthy animals was also made. Group A was treated with ivermectin at the dose rate of 0.2 mg/kg body weight (1 ml/50 kg b w) once. Group B was treated with neem dry leaves at the dose rate of 375 mg/kg body weight mixed with wheat bran for four days. Group C was kept as positive control (Infected-Untreated) and Group D was kept as negative control (Uninfected-Untreated). The faecal samples were collected on day zero pre-medication and on day 7 and 14 post-medication. The efficacies of ivermectin and neem were calculated on the basis of reduction in number of eggs per gram (EPG) of the faeces. The efficacy of ivermectin was 73.21 and 96.42% on day 7 and 14 respectively. The efficacy of neem was noted to be 22.22 and 33.33% on day 7 and 14 post-medication respectively. It was concluded that ivermectin was most effective. The blood samples were also collected on day zero (pre-medication) and on day 7 and 14 (post-medication) and were examined for hematology. Groups A, B and C had low haemoglobin values. The values get improved in groups A and B after treatments but the value further decreased in group C because this group was kept as infected control. The Hb value remained normal in group D as the animals in this group were healthy. In group C there was significant increase in eosinophils.
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Item type Current location Collection Call number Status Date due Barcode Item holds
Thesis Thesis UVAS Library
Thesis Section
Veterinary Science 1302,T (Browse shelf) Available 1302,T
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Donkeys act as draught animals and are used for a variety of purposes. Donkeys are still the "beasts of burden". Helminthes parasites, particularly strongyle nematodes, are the common inhabitants of the gastro-intestinal tracts of equines. Strongylosis is one of the most important parasitic diseases of equines. Diarrhea, anorexia, weight loss and moderate anaemia are the clinical signs in infected animal resulting in heavy mortality. The present project was therefore designed to investigate the infection rate of nematodes in donkeys, to calculate the efficacy of Ivermectin and Neem against strongylosis and to study the effect of strongylosis on various blood parameters (DLC and Hb).
Three hundred donkeys (n=300) were examined coprologically for the presence of nematodes. 167 donkeys were found infected with various parasites with the overall infection rate being 55.66%. Out of 167, 85 donkeys were infected with strongylus, 29 with trichostrongylus, 19 with trichonema, 19 with gastrodiscuss and 15 with mixed infection. So the infection rate for strongylus, trichostrongylus, trichonema, gastrodiscuss and mixed infection was 28.33%, 9.66%, 6.33%, 6.33% and 5% respectively. For drug trails thirty donkeys naturally infected with strongylosis were selected. These animals were divided into three groups A, B and C, comprising of 10 animals each. Another group D comprising of 10 healthy animals was also made. Group A was treated with ivermectin at the dose rate of 0.2 mg/kg body weight (1 ml/50 kg b w) once. Group B was treated with neem dry leaves at the dose rate of 375 mg/kg body weight mixed with wheat bran for four days. Group C was kept as positive control (Infected-Untreated) and Group D was kept as negative control (Uninfected-Untreated).
The faecal samples were collected on day zero pre-medication and on day 7 and 14 post-medication. The efficacies of ivermectin and neem were calculated on the basis of reduction in number of eggs per gram (EPG) of the faeces. The efficacy of ivermectin was 73.21 and 96.42% on day 7 and 14 respectively. The efficacy of neem was noted to be 22.22 and 33.33% on day 7 and 14 post-medication respectively. It was concluded that ivermectin was most effective. The blood samples were also collected on day zero (pre-medication) and on day 7 and 14 (post-medication) and were examined for hematology. Groups A, B and C had low haemoglobin values. The values get improved in groups A and B after treatments but the value further decreased in group C because this group was kept as infected control. The Hb value remained normal in group D as the animals in this group were healthy. In group C there was significant increase in eosinophils.

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