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The Efficacy Of Chemotherapeutic Agents Against Paramphistomum In Sheep

By: Muhammad Mashhood Hassan | Dr. Jawaria Ali Khan.
Contributor(s): Prof. Dr. Muhammad Sarwar Khan.
Material type: materialTypeLabelBookPublisher: 2011Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 1303,T Dissertation note: The present project was carried out to diagnose the paramphistomum infection in sheep and to evaluate the efficacy of oxyclozanide and albendazole and to observe the effect of paramphistomum on various blood parameters, haemoglobin estimation, erythrocytes sedimentation rate and packed cell volume. For this purpose twenty four Sheep were selected and divided into 4 groups. Each group comprised of 6 animals. Faecal samples were collected from Out Reach centre Sitar wala and its adjacent areas and out door clinic UVAS Lahore for the diagnosis of paramphistomum. The faecal and blood samples were collected on day zero pre-medication, and day 7 and 10 post-medication. The drug efficacy was checked at those animals which were positive for the paramphistomum. The animals in Group A were treated with Oxyclozanide (Zanil) at a dose rate of 15 mg/kg body weight. The animals in Group B were treated with Albendazole (Albensel) at a dose rate of 10 mg/kg body weight. The animals in Group C were kept as positive control (infected-untreated) and Group D were kept as negative control (uninfected-untreated). Eggs per gram (EPG) of the faeces were noted on day 0 day before medication. The efficacy of these drugs was calculated on the basis of reduction of eggs per gram (EPG) of faeces after treatment. Zanil showed a progressive decrease in the faecal egg counts. The efficacy of Oxyclozanide (Zanil) was 58.33% on day 7 and 83.33 % on day 10. The efficacy of Albendazole (Albensel) was 36.36% on day 7 and 56.36 % on day 10. It was observed that Oxyclozanide (Zanil) showed better efficacy than Albendazole. Haematological parameters showed different results. A marked decrease in haemoglobin was observed after the study of infected sheep and the haemoglobin value was in normal range in healthy sheep on day zero. Packed cell volume was reduced on day zero in all infected groups, but was normal in the group of healthy sheep. After the treatment these values increased towards normal range in group A and B. The erythrocyte sedimentation rate was increased after 24 hours on day zero in all infected groups A, B, and C but was normal in the group D of healthy sheep.
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The present project was carried out to diagnose the paramphistomum infection in sheep and to evaluate the efficacy of oxyclozanide and albendazole and to observe the effect of paramphistomum on various blood parameters, haemoglobin estimation, erythrocytes sedimentation rate and packed cell volume. For this purpose twenty four Sheep were selected and divided into 4 groups. Each group comprised of 6 animals.
Faecal samples were collected from Out Reach centre Sitar wala and its adjacent areas and out door clinic UVAS Lahore for the diagnosis of paramphistomum. The faecal and blood samples were collected on day zero pre-medication, and day 7 and 10 post-medication. The drug efficacy was checked at those animals which were positive for the paramphistomum. The animals in Group A were treated with Oxyclozanide (Zanil) at a dose rate of 15 mg/kg body weight. The animals in Group B were treated with Albendazole (Albensel) at a dose rate of 10 mg/kg body weight. The animals in Group C were kept as positive control (infected-untreated) and Group D were kept as negative control (uninfected-untreated).
Eggs per gram (EPG) of the faeces were noted on day 0 day before medication. The efficacy of these drugs was calculated on the basis of reduction of eggs per gram (EPG) of faeces after treatment. Zanil showed a progressive decrease in the faecal egg counts.
The efficacy of Oxyclozanide (Zanil) was 58.33% on day 7 and 83.33 % on day 10. The efficacy of Albendazole (Albensel) was 36.36% on day 7 and 56.36 % on day 10. It was observed that Oxyclozanide (Zanil) showed better efficacy than Albendazole.

Haematological parameters showed different results. A marked decrease in haemoglobin was observed after the study of infected sheep and the haemoglobin value was in normal range in healthy sheep on day zero. Packed cell volume was reduced on day zero in all infected groups, but was normal in the group of healthy sheep. After the treatment these values increased towards normal range in group A and B. The erythrocyte sedimentation rate was increased after 24 hours on day zero in all infected groups A, B, and C but was normal in the group D of healthy sheep.

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