A Study On Prevalance Of Hcv Genotypes And Risk Factors Of Hepatitis C Virus In Punjab
By: Tahira Tarar
| Miss Faiza Masood.
Contributor(s): Dr. Muhammad | Mr. Zahid Mushtaq.
Material type: 
BookPublisher: 2011Subject(s): Institute of Biochemistry & BiotechnologyDDC classification: 1336,T Dissertation note: Hepatitis C virus (HCV) was marked as major agent which causes non-A, non-B hepatitis. Various partial and complete sequences of HCV nucleotide had been identified in the world. When these sequences were compared a marked genetic heterogeneity was revealed, that suggested the existence of HCV genotypes. Recent studies have pointed out the association of different HCV genotypes with different profiles of pathogenecity, infectivity and response to antiviral therapy. In our study we used typing system based on genotype specific primers focused on HCV 5´-UTR by using PCR. Genotype specific primers were designed for genotype 1, 2a, 2b, 3a, 3b and 4. 100 samples of HCV positive patients were collected. The frequency of occurrence of genotype 2a was 4 %, 2b was 5 %, 3a was 71 %, 3b was 11% and untypeable was 9 %. Blood transfusions, therapeutic injections, reuse of needles, dental procedures, shaving practices, body piercings, jaundice, dialysis, surgery and other multiple risk factors associated with HCV were studied. Major risk factor among females was therapeutic injections and among males the major risk factor was absence of shaving precautions. The study concludes that the most prevalent genotype in Punjab province is 3a. As each genotype sequence is different, the antiviral therapy against that particular genotype is also different. The treatment would only be successful if the genotype of HCV infected patient is known. This study will help in correlating efficacy of interferon therapy with different HCV genotypes and to understand the mode of transmission for hepatitis C virus.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 1336,T (Browse shelf) | Available | 1336,T |
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Hepatitis C virus (HCV) was marked as major agent which causes non-A, non-B hepatitis. Various partial and complete sequences of HCV nucleotide had been identified in the world. When these sequences were compared a marked genetic heterogeneity was revealed, that suggested the existence of HCV genotypes. Recent studies have pointed out the association of different HCV genotypes with different profiles of pathogenecity, infectivity and response to antiviral therapy. In our study we used typing system based on genotype specific primers focused on HCV 5´-UTR by using PCR. Genotype specific primers were designed for genotype 1, 2a, 2b, 3a, 3b and 4. 100 samples of HCV positive patients were collected. The frequency of occurrence of genotype 2a was 4 %, 2b was 5 %, 3a was 71 %, 3b was 11% and untypeable was 9 %. Blood transfusions, therapeutic injections, reuse of needles, dental procedures, shaving practices, body piercings, jaundice, dialysis, surgery and other multiple risk factors associated with HCV were studied. Major risk factor among females was therapeutic injections and among males the major risk factor was absence of shaving precautions. The study concludes that the most prevalent genotype in Punjab province is 3a. As each genotype sequence is different, the antiviral therapy against that particular genotype is also different. The treatment would only be successful if the genotype of HCV infected patient is known. This study will help in correlating efficacy of interferon therapy with different HCV genotypes and to understand the mode of transmission for hepatitis C virus.
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