Identification Of Potential Drug-Drug Interactions In Prescriptions Dispensed By Community Pharmacies In The Urban
By: Muhammad Mubasher
| Ms. Huma Rasheed.
Contributor(s): Muhammad Irfan Masood | Prof. Dr.
Material type: 
BookPublisher: 2011Subject(s): Institute of Pharmaceutical Sciences ( IPS )DDC classification: 1431,T Dissertation note: Pakistan is a developing country of South Asia and health care status of the people is considerably low compared to the developed countries of World. The concept of rational prescribing is still not fully understood by health care professionals of this region of the world. This study was designed to identify the most frequently encountered potential DDIs in prescriptions dispensed in community pharmacies in Lahore. A total of 1554 DIs were identified in 655 prescriptions out of 1000 analyzed prescriptions. The identified drug interactions were classified on the basis of their type, mechanism and outcome, severity, onset, and documentation status. It was observed that alcohol-drug interactions 582 (37.45%) and DDIs 524 (33.72%) are the most frequently occurring drug interactions in our society. Although most of the identified DDIs were moderate 233 (44.38%) in severity having delayed onset 230 (43.89%) and possible documentation 214 (40.84%), incidence of rapid onset 171 (32.63%), major DDIs 88 (16.76%) was also alarming in prescriptions dispensed at community pharmacies of urban Lahore. Aspirin was the most frequently interacting drug 138 times (26.34%) and acetaminophen-orphenadrine combination with 53 (10.91%) encounters was the top interacting combination followed by aspirin-clopidogrel combination. The incidence of DDIs increased significantly with increase in the number of medicines (r value = 0.87) in a prescription. On the basis of findings, recommendations that how potential DDIs can be avoided were made.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 1431,T (Browse shelf) | Available | 1431,T |
Pakistan is a developing country of South Asia and health care status of the people is considerably low compared to the developed countries of World. The concept of rational prescribing is still not fully understood by health care professionals of this region of the world. This study was designed to identify the most frequently encountered potential DDIs in prescriptions dispensed in community pharmacies in Lahore. A total of 1554 DIs were identified in 655 prescriptions out of 1000 analyzed prescriptions. The identified drug interactions were classified on the basis of their type, mechanism and outcome, severity, onset, and documentation status. It was observed that alcohol-drug interactions 582 (37.45%) and DDIs 524 (33.72%) are the most frequently occurring drug interactions in our society. Although most of the identified DDIs were moderate 233 (44.38%) in severity having delayed onset 230 (43.89%) and possible documentation 214 (40.84%), incidence of rapid onset 171 (32.63%), major DDIs 88 (16.76%) was also alarming in prescriptions dispensed at community pharmacies of urban Lahore. Aspirin was the most frequently interacting drug 138 times (26.34%) and acetaminophen-orphenadrine combination with 53 (10.91%) encounters was the top interacting combination followed by aspirin-clopidogrel combination. The incidence of DDIs increased significantly with increase in the number of medicines (r value = 0.87) in a prescription. On the basis of findings, recommendations that how potential DDIs can be avoided were made.
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