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Evaluation Of Immunomodulatory Activity Of Meloxicam In Mice.

By: Ghulam Fatima | Dr. Aqeel Javeed.
Contributor(s): Prof. Dr. Muhammad Ashraf.
Material type: materialTypeLabelBookPublisher: 2013Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 1656,T Dissertation note: In the present study, the immunomodulatory activity of meloxicam was evaluated. For the evaluation of effect of meloxicam on cellular immunity the delayed type hypersensitivity assay (DTH) and cyclophosphamide induced neutropenia assay were performed while for humoral immunity haemagglutination assay and mice lethality test was performed. In each assay 15 mice were used, all mice were divided into 3 groups, each group was consist of 5 mice. Two groups were treated with two different doses of meloxicam (5mg/kg and 10 mg/kg) and the one group (control group) was only being administered with dimethylsulphoxide (DMSO) intraperitoneally. In DTH assay, 5mg/kg and 10mg/kg meloxicam treated groups of mice showed a significant reduction in skin thickness ( P<0.05) as compared to control group at 24hours, 48 hours and 72 hours after the challenging dose of dinitrochlorobenzene (DNCB). In cyclophosphamide induced neutropenia assay meloxicam at 10mg/kg showed a significant percentage of reduction in total leukocytes (TLC) and two types of differential leukocytes (DLC i.e lymphocytes, and neutrophils except monocytes). This significant reduction was less in 5mg/kg meloxicam treated group which in turn was less than the control group. In addition, it was observed a dose dependent reduction response in haemagglutination (HA) titre. The order of reduction in HA titre was 10mg/kg meloxicam treated group > 5mg/kg meloxicam treated group > the control group. The mortality ratio of mice in the control group, 5mg/kg meloxicam and 10 mg/kg meloxicam treated groups was 20%, 80% and 100% respectively. All the results of present study suggest that meloxicam has suppressive effect on cellular as well as on humoral component of immune system.
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In the present study, the immunomodulatory activity of meloxicam was evaluated. For the evaluation of effect of meloxicam on cellular immunity the delayed type hypersensitivity assay (DTH) and cyclophosphamide induced neutropenia assay were performed while for humoral immunity haemagglutination assay and mice lethality test was performed. In each assay 15 mice were used, all mice were divided into 3 groups, each group was consist of 5 mice. Two groups were treated with two different doses of meloxicam (5mg/kg and 10 mg/kg) and the one group (control group) was only being administered with dimethylsulphoxide (DMSO) intraperitoneally.
In DTH assay, 5mg/kg and 10mg/kg meloxicam treated groups of mice showed a significant reduction in skin thickness ( P<0.05) as compared to control group at 24hours, 48 hours and 72 hours after the challenging dose of dinitrochlorobenzene (DNCB).
In cyclophosphamide induced neutropenia assay meloxicam at 10mg/kg showed a significant percentage of reduction in total leukocytes (TLC) and two types of differential leukocytes (DLC i.e lymphocytes, and neutrophils except monocytes). This significant reduction was less in 5mg/kg meloxicam treated group which in turn was less than the control group. In addition, it was observed a dose dependent reduction response in haemagglutination (HA) titre. The order of reduction in HA titre was 10mg/kg meloxicam treated group > 5mg/kg meloxicam treated group > the control group. The mortality ratio of mice in the control group, 5mg/kg meloxicam and 10 mg/kg meloxicam treated groups was 20%, 80% and 100% respectively.
All the results of present study suggest that meloxicam has suppressive effect on cellular as well as on humoral component of immune system.

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