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Invitro Evaluation Of Microemulsion Containing Extract Of Lawsonia Inermis

By: Aysha Aslam | Dr. Sonia Khiljee.
Contributor(s): Allah Buksh Awan | Dr. Muhammad.
Material type: materialTypeLabelBookPublisher: 2013Subject(s): Institute of Pharmaceutical Sciences ( IPS )DDC classification: 1773,T Dissertation note: The objective of the present study is to develop an optimum microemulsion formulation of Lawsone, for transdermal delivery. This study also investigated the effects of surfactants and cosurfactants and oils on the percutaneous delivery of Lawsone microemulsion. Oleic acid was selected as the oil phase, Tween 80 as surfactant and Ethanol as cosurfactant of the microemulsion due to its good solubilizing capacity for the drug. The microemulsion area was identified by constructing Pseudoternary phase diagrams with different surfactant-cosurfactant mixtures (Smix) and oil. 5% Lawsone microemulsion was prepared. Transdermal permeation of Lawsone microemulsion was determined in vitro using Franz diffusion cell. In vitro permeation profiles showed that incorporation of Lawsone in microemulsion increased the permeation rate as compared to the saturated aqueous solution. The formulation passed thermodynamic stability tests were characterized for viscosity, pH and conductivity. In vitro skin permeation of these formulations was also determined. The optimum microemulsion formulation comprised of 5% Lawsone, 5% Oleic acid, 95% Tween 80 and ethanol (1:1). The formulation was found to be non-irritant to the skin. These results indicate that the type of surfactant and cosurfactant affect both the phase behaviour and transdermal drug delivery ability of microemulsion; and the studied microemulsions are potential vehicles for improved transdermal delivery of Lawsone. Keywords: Transdermal microemulsion, Lawsone, Surfactants, Cosurfactants.
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The objective of the present study is to develop an optimum microemulsion formulation of Lawsone, for transdermal delivery. This study also investigated the effects of surfactants and cosurfactants and oils on the percutaneous delivery of Lawsone microemulsion. Oleic acid was selected as the oil phase, Tween 80 as surfactant and Ethanol as cosurfactant of the microemulsion due to its good solubilizing capacity for the drug. The microemulsion area was identified by constructing Pseudoternary phase diagrams with different surfactant-cosurfactant mixtures (Smix) and oil. 5% Lawsone microemulsion was prepared. Transdermal permeation of Lawsone microemulsion was determined in vitro using Franz diffusion cell. In vitro permeation profiles showed that incorporation of Lawsone in microemulsion increased the permeation rate as compared to the saturated aqueous solution. The formulation passed thermodynamic stability tests were characterized for viscosity, pH and conductivity. In vitro skin permeation of these formulations was also determined. The optimum microemulsion formulation comprised of 5% Lawsone, 5% Oleic acid, 95% Tween 80 and ethanol (1:1). The formulation was found to be non-irritant to the skin. These results indicate that the type of surfactant and cosurfactant affect both the phase behaviour and transdermal drug delivery ability of microemulsion; and the studied microemulsions are potential vehicles for improved transdermal delivery of Lawsone.
Keywords: Transdermal microemulsion, Lawsone, Surfactants, Cosurfactants.

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